Results 61 to 70 of about 3,438,712 (289)

Iron‐Mediated Release of Aged Dissolved Organic Carbon From Waterlogged Peatland Under Warming

Advanced Science, EarlyView.
This study conducts a five‐year in situ warming experiment in high‐altitude peatlands to examine dissolved organic carbon (DOC) release. The study shows that warming promotes the release of plant‐derived modern DOC in drained peatlands, but amplifies aquatic export of century‐old DOC from waterlogged peatlands via Fe‐mediated DOC mobilization—a ...
Guohua Dai, Zhiying Yang, Zongguang Liu, Wanjia Hu, Lixiao Ma, Enze Kang, Wanqing Luo, Yunpeng Zhao, Chengzhu Liu, Juan Jia, Ting Liu, Chen He, Quan Shi, Jianliang Liu, Yongheng Gao, Huai Chen, Hailong Zhang, Meixun Zhao, Xiaojuan Feng   +18 more
wiley   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Characterization of lead-phytochelatin complexes by nano-electrospray ionization mass spectrometry

Frontiers in Microbiology, 2012
The role of phytochelatins (PCn, metal-binding oligopeptides with the general structure (γGlu - Cys)n - Gly (n = 2- 11)) in metal detoxification is assumed to be based on immobilization of metals, which prevents binding of metals to important ...
Christian eScheidegger, Christian eScheidegger, Marc J--F. Suter, Marc J--F. Suter, Renata eBehra, Laura eSigg, Laura eSigg   +6 more
doaj   +1 more source

Multicenter Study Using Desorption-Electrospray-Ionization-Mass-Spectrometry Imaging for Breast-Cancer Diagnosis

, 2018
The histological and molecular subtypes of breast cancer demand distinct therapeutic approaches. Invasive ductal carcinoma (IDC) is subtyped according to estrogen-receptor (ER), progesterone-receptor (PR), and HER2 status, among other markers. Desorption-
Luis Otávio Sarian (5759609), Geisilene R. Paiva, Chandandeep Nagi, Luis Otávio Sarian, Livia S. Eberlin, Stacey A. Carter (5759606), Jialing Zhang, Stacey A. Carter, John Q. Lin (5622686), Marcos N. Eberlin (745128), Robert Tibshirani, Raquel M. Rodrigues-Peres, Kyana Y. Garza (5622683), Jonathan H. Young, Chandandeep Nagi (286802), Livia S. Eberlin (461381), Raquel M. Rodrigues-Peres (5759597), Geisilene R. Paiva (5759603), Andreia M. Porcari, Marcos N. Eberlin, Jialing Zhang (1317267), Jonathan H. Young (5759600), Andreia M. Porcari (5759594), Robert Tibshirani (196), Kyana Y. Garza, John Q. Lin   +25 more
core   +1 more source

Precursor ion scanning for detection and structural characterization of heterogeneous glycopeptide mixtures [PDF]

, 2002
The structure of N-linked glycans is determined by a complex, anabolic, intracellular pathway but the exact role of individual glycans is not always clear.
Gill, A C, Lilley, Kathryn, Ritchie, Mark A, Deery, Michael J, Lilley, K, Gill, Andrew C, Ritchie, M A, Deery, M J   +7 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

The path of biomolecular mass spectrometry into open research

Nature Communications, 2019
Originally designed for measuring isotope abundances and elemental masses, mass spectrometry is becoming a mainstay across life sciences. As electrospray ionization of biomolecules turns 30 and the Orbitrap mass analyzer 20, we take this opportunity to ...
doaj   +1 more source

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice

Journal of Lipid Research, 2003
Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains.
Keiko Tadano-Aritomi, Junko Matsuda, Hirokazu Fujimoto, Kunihiko Suzuki, Ineo Ishizuka   +4 more
doaj   +1 more source

Characterisation of pharmaceutical and polymer formulations by novel mass spectrometry approaches [PDF]

Since its inception at the beginning of the twentieth century, the field of mass spectrometry has progressed from the realm of physics to an analytical tool that can be found in many fields of science.
Snelling, Jonathon R.
core  

Peak intensity prediction in MALDI-TOF mass spectrometry: A machine learning study to support quantitative proteomics [PDF]

, 2008
Timm W, Scherbart A, Boecker S, Kohlbacher O, Nattkemper TW. Peak intensity prediction in MALDI-TOF mass spectrometry: A machine learning study to support quantitative proteomics. BMC Bioinformatics.
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Wiebke A Timm, Boecker, Sebastian, Kohlbacher, Oliver, Scherbart Alexandra, Kohlbacher Oliver, Sebastian Bocker, Tim W Nattkemper, Alexandra Scherbart, Scherbart, Alexandra, Timm, Wiebke, Timm Wiebke, Oliver Kohlbacher, Böcker Sebastian   +14 more
core   +1 more source