Results 41 to 50 of about 3,438,712 (289)

Performing native mass spectrometry analysis on therapeutic antibodies [PDF]

, 2013
Since the introduction of “soft” ionization techniques, the role of mass spectrometry (MS) in the field of structural biology has increasingly expanded.
Heck, A.J.R., Rosati, S, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Thompson, N.J.   +4 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Electrospray ionization tandem mass spectrometry of monoketone curcuminoids [PDF]

Rapid Communications in Mass Spectrometry, 2020
Rationale Although monoketone curcuminoids (MKCs) have been largely investigated due to their biological activities, data on the gas‐phase fragmentation reactions of protonated MKCs under collision‐induced dissociation (CID) conditions are still scarce.
Tatiana M. Vieira, Renato P. Orenha, Eduardo J. Crevelin, Saulo S.P. Furtado, Ricardo Vessecchi, Renato L.T. Parreira, Antônio E.M. Crotti   +6 more
openaire   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

PCR–Electrospray Ionization Mass Spectrometry [PDF]

The Journal of Molecular Diagnostics, 2012
During the past 20 years, microbial detection methods that are genetically based, such as real-time PCR and peptide nucleic acid fluorescent hybridization, coexisted with traditional microbiological methods and were typically based on the identification of individual genetic targets.
Wolk, Donna M., Kaleta, Erin J., Wysocki, Vicki H.   +2 more
openaire   +2 more sources

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Multilayer Self‐Limiting Electrospray Deposition via Stepped Voltage Bias

Advanced Engineering Materials, EarlyView.
Self‐limiting electrospray deposition (SLED) uses a high voltage to generate and deposit a charged payload on a target surface. The coating retains its charge, repelling newly arriving material. SLED thickness can be decreased by applying a secondary bias to the target.
Madhuri Deb, S. Rahman Pejman, Alexander Jakimowicz, Jonathan P. Singer   +3 more
wiley   +1 more source

Volatile Relay Biosensing and Mobile Phone Imaging for Detection of Influenza Virus

Advanced Functional Materials, EarlyView.
Detection of volatile organic compounds is performed via a coupled enzymatic assay with mobile phone detection of the signal. Specific application demonstrated herein is the detection of influenza virus, across multiple levels of biological complexity, up to patient‐derived samples.
Dante G. Andersen, Josefine H. Jakobsen, Mikkel Høj Nielsen, Shreyans Chatterjee, Detlef Michel, Jan Münch, Rüdiger Gross, Alexander N. Zelikin   +7 more
wiley   +1 more source

A Non-Covalent Dimer Formation of Quaternary Ammonium Cation with Unusual Charge Neutralization in Electrospray-Ionization Mass Spectrometry

Molecules, 2021
Specific and nonspecific non-covalent molecular association of biomolecules is characteristic for electrospray-ionization mass spectrometry analysis of biomolecules.
Paulina Grocholska, Marta Kowalska, Robert Wieczorek, Remigiusz Bąchor   +3 more
doaj   +1 more source

Multifunctional Solid Polymer Electrolyte Films Integrating Intrinsic Self‐Healing and Dual Photo‐/pH‐Responsive Ionic Sensing for Intelligent Flexible Electronics

Advanced Functional Materials, EarlyView.
Multifunctional solid polymer electrolyte (SPE) films integrating intrinsic self‐healing, mechanical stretchability, and dual photo‐ and pH‐responsive ionic conductivity are developed. Constructed from thermoplastic polyurethane (TPU) and hydrogen‐bonded poly(thiourea triethylene glycol) (PTUEG3), these films form a dynamic supramolecular network ...
Mei‐Li Li, Tse‐Yu Lo, Chia‐Wei Chang, Yen‐Shen Hsu, Chen‐Yi Chien, Yu‐Yao Huang, Chia‐Ti Wu, Chun‐Chi Chang, Bo‐Chen Chen, Heng‐Hsuan Su, Chin‐Hua Liu, Che‐Ning Yeh, Jiun‐Tai Chen   +12 more
wiley   +1 more source