Results 101 to 110 of about 234,445 (274)
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Modal Rationalism and Constructive Realism: Models and Their Modality [PDF]
, 2010 I present a case for a rapprochement between aspects of rationalism and scientific realism, by way of a general framework employing modal epistemology and elements of 2-dimensional semantics (2DS). My overall argument strategy is meta-inductive: The bulk
Kallfelz, William
core
A Heideggerian Perspective on Speculative Realism
, 2023 In spite of phenomenology’s sometimes overtly antithetical relation to realism, recent literature in speculative realism draws heavy on phenomenological sources in order to strengthen its position.
Miechels, Tim
core
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Deriving the Spiritual from the Material: A Speculatively Realist Perspective
ReligionsThe existence of the spiritual can be deduced from knowledge of the material. There is an inherent affinity between speculation and spirituality: an embrace of gaps in knowledge.
Ian McLaughlin
doaj +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Chamanes y psicodelia andina: (en)cantos comunitarios en un texto de Mónica Ojeda
ConfluenzeIn a context of global disenchantment, ecological crisis, and neoliberal exhaustion, contemporary narratives must rethink ways of inhabiting the world beyond environmental catastrophe.
Federica Moscatelli
doaj +1 more source