Results 101 to 110 of about 59,319 (299)
Historisieren und/oder überwinden? Foucault im Kontext "Neuer Materialismen"
Genealogy+Critique, 2015 In the course of recent calls for a new materialist or realist turn in the humanities, Foucault's contributions to our thinking of the present have come under scrutiny.
Corinne Kaszner
doaj +2 more sources
Instantiation in Trope Theory [PDF]
, 2018 The concept of instantiation is realized differently across a variety of metaphysical theories. A certain realization of the concept in a given theory depends on what roles are specified and associated with the concept and its corresponding term as well ...
Fisher, A. R. J.
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
"To think a world without thought": Negotiating Speculative Realism in a Digital Humanities Practice
Digital Studies, 2014 In John Napier’s classic study of the structure, function, and behavior of the human hand, he states that "[i]magination is basic to tool-making. All human-made tools start off as chunks of undifferentiated material, which are then shaped according to ...
Aaron Mauro
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Mark Eli Kalderon, "Sympathy in Perception" [PDF]
, 2018 Mark Eli Kalderon's book boldly positions itself as a work in speculative metaphysics. Its point of departure is the familiar distinction between presentational and representational philosophies of perception. Kalderon notes that the latter has been more
Legg, Catherine, Reynolds, Jack Alan
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Antiphilosophy: Jean Epstein and speculative realism
Intexto, 2020 This article aims to propose a dialogue between Jean Epstein's movies and theory and speculative realism. The interaction of subjective and objective forces in cinema is a compelling field of investigation for a speculative realist, and the epsteinian conviction that cinema opens us to new domains of world knowledge is absolutely in tune with that ...
openaire +2 more sources
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source