Results 51 to 60 of about 227,399 (278)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Speculations VI

open access: yes, 2015
In this sixth issue of Speculations, a serial imprint created to explore post-continental philosophy and speculative realism, a wide range of contemporary philosophical issues pertaining to the contemporary philosophical scene is touched upon, from the ...

core   +1 more source

Speculative realism

open access: yes, 2007
This is a lightly edited transcript of an inaugural (April 27, 2007) Speculative Realism event at Goldsmiths College, University of ...
Harman, Graham
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Group Structural Realism [PDF]

open access: yes, 2009
We present a precise form of structural realism, called 'group structural realism,' which identifies 'structure' in quantum theory with symmetry groups.
Roberts, Bryan W., Bryan W. Roberts
core   +1 more source

"TRANSNOUMENALISM" AND OBJECT-ORIENTED ONTOLOGY: REAL, IMAGINARY AND CONSTITUTION OF OBJECTIVITY WITHIN THE FRAMEWORK OF SPECULATIVE REALISM

open access: yesВісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2018
The article investigates place of an object in the field of speculative realism in general and objectoriented ontology in particular. It describes object’s special and ambiguous position given to it by OOO as opposed to “correlational” approach.
Vitalii O. Starovoit
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Speculative Realism in the Context of Contemporary Philosophical Thought

open access: yes, 2020
На прикладі філософів, що передовсім асоціюються зі спекулятивним реалізмом (Ґрема Гармана, Квентіна Меясу, Іена Гамільтона Ґранта і Рея Брасьє), автор статті досліджує місце цього явища в контексті сучасної філософії.
Корчевний, Василь
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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