Results 61 to 70 of about 234,445 (274)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Speculative Realism: Resources on an Emerging Discipline [PDF]
, 2010 Review of resources related to the "Speculative Realism" or "Object-Oriented Philosophy" movement that sprung up in the late ...
Eric Phetteplace
core
Speculative Realism in the Context of Contemporary Philosophical Thought
, 2020 На прикладі філософів, що передовсім асоціюються зі спекулятивним реалізмом (Ґрема Гармана, Квентіна Меясу, Іена Гамільтона Ґранта і Рея Брасьє), автор статті досліджує місце цього явища в контексті сучасної філософії.
Корчевний, Василь
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Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2018 The article investigates place of an object in the field of speculative realism in general and objectoriented ontology in particular. It describes object’s special and ambiguous position given to it by OOO as opposed to “correlational” approach.
Vitalii O. Starovoit
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Realism and Dialectic: The Speculative Turn and the History of the Nineteenth-Century European Novel
, 2020 A narrative impulse and a scenic impulse: as Fredric Jameson persuasively argues in The Antinomies of Realism, the history of literary realism has been shaped by the dialectic between these two competing drives, each identified by a specific temporality.
Stefano Ercolino
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, 2015 34 pagesQuentin Meillassoux, like his mentor Alain Badiou, is sometimes accused by his critics of “fetishizing mathematics.” Without embracing the negative judgment implied in such a charge, this essay asks: what might be gained by taking seriously the ...
McNulty, Tracy, Tracy McNulty
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