Results 71 to 80 of about 2,130 (284)

Speculative realism

open access: yes, 2007
This is a lightly edited transcript of an inaugural (April 27, 2007) Speculative Realism event at Goldsmiths College, University of ...
Harman, Graham
core  

THE END OF WHAT? PHENOMENOLOGY VS. SPECULATIVE REALISM

open access: yes, 2021
Phenomenology has recently come under attack from propo-nents of speculative realism. In this paper, I present and assess the criticism, and argue that it is either superficial and sim-plistic or lacks ...
Zahavi, Dan
core  

Speculative Fetishism [PDF]

open access: yes, 2015
34 pagesQuentin Meillassoux, like his mentor Alain Badiou, is sometimes accused by his critics of “fetishizing mathematics.” Without embracing the negative judgment implied in such a charge, this essay asks: what might be gained by taking seriously the ...
McNulty, Tracy, Tracy McNulty
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Speculative Realisms and Religion

open access: yesCalenda, 2013
The Journal ThéoRèmes is devoting a special issue to this presence of the religious question in various philosophical studies related to “Speculative realism” or even “object-oriented ontologies”, in order both to deepen the internal understanding of this question, and to develop critical approaches. We welcome contributions from a range of disciplines
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Speculative Tate

open access: yes, 2014
Speculative Realism is a term that is used to describe an approach that attempts to consider art, politics, nature and thought beyond the confines of human finitude.
Pendrell, Luke
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

The Melancholia of Extinction: Psychoanalysis and Speculative Realism at the End

open access: yesOpen Philosophy
This article considers the end through cinema, psychoanalysis and speculative realism. Among contemporary end-of-the-world films Lars von Trier’s Melancholia stands out for its emphasis on the simultaneity of psychic and cosmic annihilation.
Tyrer Ben
doaj   +1 more source

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