Results 61 to 70 of about 2,073,624 (303)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Atypical delayed auditory feedback effect and Lombard effect on speech production in high-functioning adults with autism spectrum disorder

Frontiers in Human Neuroscience, 2015
Individuals with autism spectrum disorder (ASD) show impaired social interaction and communication, which may be related to their difficulties in speech production.
I-Fan eLin, Takemi eMochida, Kosuke eAsada, Satsuki eAyaya, Shin-ichiro eKumagaya, Masaharu eKato, Masaharu eKato   +6 more
doaj   +1 more source

End-to-End Optimization of Source Models for Speech and Audio Coding Using a Machine Learning Framework

, 2019
Speech coding is the most commonly used application of speech processing. Accumulated layers of improvements have however made codecs so complex that optimization of individual modules becomes increasingly difficult. This work introduces machine learning
Bäckström, Tom, Tom Bäckström
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Super-Wideband Spectral Envelope Modeling for Speech Coding

, 2019
Significant improvements in the quality of speech coders have been achieved by widening the coded frequency range from narrowband to wideband. However, existing speech coders still employ a limited band source-filter model extended by parametric coding ...
Fuchs, Guillaume, Bäckström, Tom, Guillaume Fuchs, Chamran Ashour, Ashour, Chamran, Tom Bäckström   +5 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Wavelets for intonation modeling in HMM speech synthesis [PDF]

, 2013
The pitch contour in speech contains information about different linguistic units at several distinct temporal scales. At the finest level, the microprosodic cues are purely segmental in nature, whereas in the coarser time scales, lexical tones, word ...
Suni, Antti Santeri, Alku, Paavo, Vainio, Martti, Suni, Antti, Aalto, Daniel, Raitio, Tuomo   +5 more
core  

A Formant Modification Method for Improved ASR of Children’s Speech

, 2022
Differences in acoustic characteristics between children’s and adults’ speech degrade performance of automatic speech recognition systems when systems trained using adults’ speech are used to recognize children’s speech.
Alku, Paavo, Kurimo, Mikko, Kadiri, Sudarsana, Kathania, Hemant   +3 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source