Results 81 to 90 of about 1,116,535 (288)

High-Speed Route Improvement Optimizer

Transportation Research Record: Journal of the Transportation Research Board, 2012
The most common near-term approach to upgrading railway corridors to achieve high speeds is by incremental improvement. Existing infrastructure or rolling stock can be improved in various ways to allow for increasing speeds and reducing travel time along a route.
Lai, Yung-Cheng, Huang, Po-Wen
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Optimization of Proportional-Integral-Derivative Parameters for Speed Control of Squirrel-Cage Motors with Seahorse Optimization

Electrica
The two different motion behaviors of seahorses in nature served as inspiration for the seahorse optimization (SHO) method, which is a new metaheuristic swarm intelligence-based approach to solving fundamental engineering problems.
Yunus Emre Ekici, Ozan Akdağ, Ahmet Arif Aydın, Teoman Karadağ   +3 more
doaj   +1 more source

Design of high speed proprotors using multiobjective optimization techniques [PDF]

An integrated, multiobjective optimization procedure is developed for the design of high speed proprotors with the coupling of aerodynamic, dynamic, aeroelastic, and structural criteria.
Chattopadhyay, Aditi, Mccarthy, Thomas R.   +1 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Detection speed optimization of the OI-RD microscope for ultra-high throughput screening. [PDF]

Biomed Opt Express, 2023
Zhang H, Xu M, Li H, Mai X, Sun J, Mi L, Ma J, Zhu X, Fei Y.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Wireless communication network optimization scheme for high-speed railway based on MEC

Dianxin kexue, 2019
The optimization scheme of high-speed railway wireless communication network based on MEC was proposed,in order to achieve the optimization of high-speed railway wireless communication network and meet the needs of safe,reliable and efficient multi ...
Bin LI
doaj   +2 more sources

Elite Opposition-Based Social Spider Optimization Algorithm for Global Function Optimization

Algorithms, 2017
The Social Spider Optimization algorithm (SSO) is a novel metaheuristic optimization algorithm. To enhance the convergence speed and computational accuracy of the algorithm, in this paper, an elite opposition-based Social Spider Optimization algorithm ...
Ruxin Zhao, Qifang Luo, Yongquan Zhou
doaj   +1 more source