Results 111 to 120 of about 1,157,151 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Performance of the electrical controls for the Mini-Brayton system [PDF]
The design theory and performance of a breadboard of the proposed Mini-Brayton electrical control system is presented. The Mini-Brayton is a nuclear isotope powered dynamic power conversion system. Testing was performed with an electronic simulation of a
Birchenough, A. G.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Gong-kuang zidonghua, 2013 In view of problem of bigger speed difference between frequency levels in high frequencies in speed regulation technology of six-pulse-wave AC/AC frequency converter, the paper proposed a closed-loop voltage and speed regulation method based on six-pulse-
LI Gao-ju, DU Qing-na
doaj
Network Neutrality: A Research Guide [PDF]
, 2013 The conclusion in a research handbook should emphasise the complexity of the problem than trying to claim a one-size-fits-all solution. I have categorised net neutrality into positive and negative (content discrimination) net neutrality indicating the ...
Marsden, Christopher T
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Design of a fractional control using performance contours. Application to an electromechanical system [PDF]
, 2003 The article proposes a frequency-based method to design a controller ensuring dynamic behavior of a closed-loop control: the first overshoot of the step response in the tracking mode or in the regulation mode, the damping ratio and the natural frequency ...
Lanusse, Patrick +2 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Research status and development of control technology for mine hoist
Gong-kuang zidonghua, 2013 The paper analyzed status and development process of DC and AC mine hoist control system at home and abroad. It emphatically introduced application of three frequency-conversion speed-regulation systems based on double three-level topology in control ...
SU Chang-sheng
doaj
Propfan noise propagation [PDF]
The unconventional supersonic tip speed of advanced propellers has led to uncertainties about Propfan's noise acceptability and compliance with Federal Aviation Noise Regulation (FAR 36).
George, Albert R., Sim, Ben WEL-C.
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