Results 141 to 150 of about 1,157,151 (303)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The NASA High-Speed Research Program [PDF]
Since its inception, one of NASA's commitments has been to develop the technology to advance aeronautics. As such, a new High-Speed Research Program was activated to develop the technology for industry to build a High-Speed Civil Transport - a second ...
Beam, Sherilee F.
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Scarcity, regulation and endogenous technical progress [PDF]
This paper studies to which extent a firm using a scarce resource input and facing environmental regulation, can still manage to have a sustainable growth of output and profits.
Natali HRITONENKO +2 more
core
Speed regulation of genetic cascades allows for evolvability in the body plan specification of insects. [PDF]
Proc Natl Acad Sci U S A, 2017 Zhu X +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Research of Full Range Speed-regulation System Based on Bivariate 6-pulse Wave AC-AC Converter
Gong-kuang zidonghua, 2010 The paper proposed a design scheme of full range speed-regulation system based on bivariate 6-pulse wave AC-AC converter. It analyzed control principle of bivariate 6-pulse wave AC-AC converter, introduced characteristics and design of main circuit and ...
JIA Ji-guang, DU Shao-tong
doaj
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Research on Traction Speed Regulation and Braking Device of Pipeline Intelligent Plugging Robot
工程科学与技术ObjectiveWith increasing pipeline mileage and service time, more pipelines are being damaged due to environmental corrosion and human factors. This damage results in interruptions in transport and leakage of oil and gas, which in turn causes economic ...
TANG Yang +3 more
doaj
RESEARCH ON FUZZY CONTROL SIMULATION OF CVT RATIO BASED ON ENGINE SPEED REGULATION CHARACTERISTICS
Jixie qiangdu, 2019 According to the load characteristics and speed regulation characteristics of the engine,the steady-state torque model is established and the optimum power and economy curves of engine are determined. Then the engine target speed is obtained by using the
GUO Wei, JIA GaoXiang, ZHANG Wu, CHEN Ya
doaj