Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Exploring the Associations Between Affective and Non-Affective Cognitive Domains in Mood Disorders and Healthy Controls Using Network Analysis. [PDF]
Kjærstad HL +5 more
europepmc +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Urban-rural differences in transpiration patterns of <i>Pinus tabuliformis</i> and environmental drivers. [PDF]
Liu H, Wang J, Sun X, Zheng Z, Zhou W.
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Optimization of constant-speed control algorithm for high-speed EMUs
Constant-speed control is deemed one of the core control functions for high speed EMUs, with accuracy being crucial for ensuring smooth operation. Given the complex operational environments of trains, ensuring the accuracy of constant-speed control for ...
XIONG Yan +3 more
doaj
Upper Limbs Movement Frequency: Connection to Swimming Performance and Kinematics. [PDF]
Papadopoulos K +2 more
europepmc +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Intelligent Monitoring and Dynamic Regulation Equipment and Software Development for the Equal-Pressure Fully Mechanized Mining Face in the Sandaogou Coal Mine. [PDF]
Wang Z +8 more
europepmc +1 more source

