Results 91 to 100 of about 726,910 (390)

Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging

Immunity & Ageing, 2023
Background Morphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation.
Jintao Zhuang, Xiangping Li, Jiahui Yao, Xiangzhou Sun, Jiumin Liu, Hua Nie, Yang Hu, Xiangan Tu, Huang Liu, Weibing Qin, Yun Xie   +10 more
doaj   +1 more source

A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome

Asian Journal of Andrology, 2016
Sperm DNA damage is prevalent among infertile men and is known to influence natural reproduction. However, the impact of sperm DNA damage on assisted reproduction outcomes remains controversial.
L. Simon, A. Zini, A. Dyachenko, A. Ciampi, D. Carrell   +4 more
semanticscholar   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

Translational Andrology and Urology, 2017
Recent studies show that spermatozoal DNA integrity is essential for normal fertilization and transmission of paternal genetic information to the offspring.
M. Basar, S. Kahraman
semanticscholar   +1 more source

Kidney Stone Dissolution By Tetherless, Enzyme‐Loaded, Soft Magnetic Miniature Robots

Advanced Healthcare Materials, EarlyView.
Wireless magnetic robots are developed for kidney stone dissolution. The robots navigate through a urinary tract model from bladder and ureter to renal pelvis with the help of external magnetic fields. The filaments are loaded with urease enzyme which catalyzes urea to carbon dioxide and ammonia, thereby increasing pH to basic regime and supporting ...
Afarin Khabbazian, Lauren Kwong, Aaron Lewis, Erica Liu, Noura Abdelrazec, Anna C. Bakenecker, Nil Fontanals, Guillem Lopez, Samuel Sánchez, Juan Manuel Lopez, Brian Carrillo, Monica Farcas, Chris Kallweit, Alfred C. H. Yu, Mir Behrad Khamesee, Veronika Magdanz   +15 more
wiley   +1 more source

Sperm allocation strategies in a sperm heteromorphic insect [PDF]

Current Zoology, 2019
AbstractTheories predict that in polyandrous species, the focal male should increase sperm allocation per mate in the presence of rivals to gain greater share of paternity, but in the presence of additional mates, he should reduce sperm allocation per mate to save sperm for insemination of more mates.
Xiong Zhao He, Kambiz Esfandi, Kambiz Esfandi, Qiao Wang   +3 more
openaire   +3 more sources

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Does the FNA sperm retrieval failure prediction model work well for current NOA individuals undertaking risk screening before the operation? Model validation, high-risk population identification and potential alternative sperm retrieval exploration

BMC Medical Informatics and Decision Making
Background Non-obstructive azoospermia (NOA), the severe type of male infertility. The objective of this study was to evaluate the predictive accuracy of a prediction model of sperm retrieval failure with fine needle aspiration (FNA).
Xiaohui Jiang, Dingming Li, Yi Zheng, Yinxian Li, Hengzhou Bai, Guicheng Zhao, Yi Zhang, Yue Ma   +7 more
doaj   +1 more source

The Role of Sperm Morphology Standards in the Laboratory Assessment of Bull Fertility in Australia

Frontiers in Veterinary Science, 2021
The lack of standardization in the laboratory assessment of semen questions the reliability of semen analysis, and makes meaningful interpretation of these evaluations impossible.
V.E.A. Perry, V.E.A. Perry, V.E.A. Perry
doaj   +1 more source

Evidence of the presence of calcium/calmodulin-dependent protein kinase IV in human sperm and its involvement in motility regulation [PDF]

, 2005
The mechanisms involved in the regulation of mammalian sperm motility are not well understood. Calcium ions (Ca(2+)) have been suggested to play a key role in the maintenance of motility; nevertheless, how Ca(2+) modulates this process has not yet been ...
Buffone, Mariano Gabriel, Chertihin, Olga, Herr, John C,, Jha, Kula N., Marin Briggiler, Clara Isabel, Vazquez, Monica Hebe, Visconti, Pablo E.   +6 more
core   +1 more source