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Sperm DNA Fragmentation: Consequences for Reproduction
2019DNA fragmentation, or the accumulation of single- and double-strand DNA breaks, is a common property of sperm, and an increase in the level of sperm DNA fragmentation is known to influence natural reproduction. The effect of sperm DNA fragmentation on male infertility and assisted reproductive treatment (ART) outcomes remains controversial and is one ...
Luke, Simon +2 more
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Sperm DNA Fragmentation and Fertility
Elevated levels of sperm deoxyribonucleic acid (DNA) fragmentation (SDF) have been associated with several adverse reproductive outcomes, including: lower natural and assisted reproductive technology (ART) pregnancy rates, abnormal embryo development, and recurrent pregnancy loss.Jessica, Marinaro, Peter N, Schlegel
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Sperm DNA Fragmentation: Mechanisms of Origin
2019Spermatozoa have the task to deliver an intact paternal genome to the oocyte and to support a successful embryo development. The high levels of sperm DNA fragmentation (sDF) found in sub-/infertile men threat human reproduction and health of the offspring.
Muratori, Monica +3 more
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Sperm DNA fragmentation is related to sperm morphological staining patterns
Reproductive BioMedicine Online, 2015In this prospective comparative study, sperm DNA fragmentation (sDNAfrag) was compared at each step of a sequential semen preparation, with semen parameters according to their degree of severity. At each step (fractions) of the sequential procedure, sDNAfrag was determined: fresh (Raw), after gradient centrifugation, washing, and swim-up (SU) for 70 ...
Rosália, Sá +4 more
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Sperm DNA Fragmentation and Base Oxidation
2013Sperm DNA damage has been shown to be a valuable diagnostic and prognostic biomarker for male infertility and assisted reproductive treatment (ART) outcome. It is linked to every fertility checkpoint from reduced fertilization rates, lower embryo quality and pregnancy rates to higher rates of spontaneous miscarriage and childhood diseases.
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Assessing Sperm DNA Fragmentation with the Sperm Chromatin Dispersion Test
2010The sperm cell has evolved to transmit a paternal haploid genome to the oocyte and form a new embryo. Therefore, it is essential that the integrity of this genome be evaluated as part of the standard semen analysis. The assessment of DNA fragmentation is consequently considered as an important parameter of sperm quality. The Sperm Chromatin Dispersion (
José Luis, Fernández +3 more
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The effect of sperm DNA fragmentation on ICSI outcomes depending on oocyte quality
Andrology, 2023Amanda Souza Setti +2 more
exaly