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Sperm DNA fragmentation: causes and identification
Zygote, 2019SummarySperm DNA fragmentation is referred to as one of the main causes of male infertility. Failures in the protamination process, apoptosis and action of reactive oxygen species (ROS) are considered the most important causes of DNA fragmentation.
Thais Rose dos Santos Hamilton +1 more
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Sperm DNA Fragmentation: Consequences for Reproduction
2019DNA fragmentation, or the accumulation of single- and double-strand DNA breaks, is a common property of sperm, and an increase in the level of sperm DNA fragmentation is known to influence natural reproduction. The effect of sperm DNA fragmentation on male infertility and assisted reproductive treatment (ART) outcomes remains controversial and is one ...
Luke, Simon +2 more
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Sperm DNA fragmentation is a novel biomarker for early pregnancy loss.
Reproductive Biomedicine Online, 2020RESEARCH QUESTION Spontaneous pregnancy loss affects 10-15% of couples, with 1-2% suffering recurrent pregnancy loss and 50% of miscarriages remaining unexplained.
L. Haddock +5 more
semanticscholar +1 more source
Reproductive Toxicology, 2019
Sperm DNA fragmentation has been suggested as a predictor of pregnancy of intrauterine insemination (IUI), but the controversy still exists. Then a meta-analysis was performed to evaluate the association between sperm DNA fragmentation and reproductive ...
Qing Chen +3 more
semanticscholar +1 more source
Sperm DNA fragmentation has been suggested as a predictor of pregnancy of intrauterine insemination (IUI), but the controversy still exists. Then a meta-analysis was performed to evaluate the association between sperm DNA fragmentation and reproductive ...
Qing Chen +3 more
semanticscholar +1 more source
Sperm DNA fragmentation in men with malignancy
Fertility and Sterility, 2013To determine if men with malignancy have increased sperm DNA fragmentation compared with men presenting for sperm donation.Retrospective observational study.Tertiary-level fertility center.Eighty-nine men with cancer presenting for prophylactic semen cryopreservation and 35 men presenting for sperm donation.None.Sperm DNA fragmentation index (DFI ...
McDowell, Simon +4 more
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Sperm DNA Fragmentation and Base Oxidation
2013Sperm DNA damage has been shown to be a valuable diagnostic and prognostic biomarker for male infertility and assisted reproductive treatment (ART) outcome. It is linked to every fertility checkpoint from reduced fertilization rates, lower embryo quality and pregnancy rates to higher rates of spontaneous miscarriage and childhood diseases.
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Sperm DNA fragmentation: awakening the sleeping genome
Biochemical Society Transactions, 2007We have recently demonstrated that mammalian spermatozoa have the ability to degrade their DNA by a mechanism that is similar to apoptosis in somatic cells. When this mechanism is activated, the DNA is first degraded into loop-sized fragments by TOP2B (topoisomerase IIB).
J A, Shaman, Y, Yamauchi, W S, Ward
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Sperm DNA fragmentation is related to sperm morphological staining patterns
Reproductive BioMedicine Online, 2015In this prospective comparative study, sperm DNA fragmentation (sDNAfrag) was compared at each step of a sequential semen preparation, with semen parameters according to their degree of severity. At each step (fractions) of the sequential procedure, sDNAfrag was determined: fresh (Raw), after gradient centrifugation, washing, and swim-up (SU) for 70 ...
Rosália, Sá +4 more
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Assessing Sperm DNA Fragmentation with the Sperm Chromatin Dispersion Test
2010The sperm cell has evolved to transmit a paternal haploid genome to the oocyte and form a new embryo. Therefore, it is essential that the integrity of this genome be evaluated as part of the standard semen analysis. The assessment of DNA fragmentation is consequently considered as an important parameter of sperm quality. The Sperm Chromatin Dispersion (
José Luis, Fernández +3 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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