Results 81 to 90 of about 2,944,740 (334)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Morphological Parameters of 29994 sperm in a fertile male population—based on Papanicolaou staining and SSA-II Plus

Frontiers in Endocrinology
ObjectiveThis study aims to provide reference data for sperm morphology in a healthy, fertile male population providing a foundation for future studies on male infertility assessment and sperm selection in assisted reproductive technologies.MethodsThe ...
Longlong Fu, Fang Zhou, Guoping Chen, Renpei Yuan, Wenjie Li, Shi Qiu, Liang Tang, Wenshu Liu, Yiqun Gu, Wenhong Lu   +9 more
doaj   +1 more source

Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination

F&S Reports, 2021
Objective: To determine the effect of sperm morphology from the specific sample used for intrauterine insemination (IUI) on clinical pregnancy rates (CPR). Design: Prospective cohort study. Setting: Academic fertility clinic.
Jamie Stanhiser, M.D., M.S.C.R., Jennifer E. Mersereau, M.D., M.S.C.I., Daquan Dock, B.S., Caitlin Boylan, B.S., Hunter Caprell, B.S., R. Matthew Coward, M.D., Dara S. Berger, Ph.D., Marc Fritz, M.D.   +7 more
doaj   +1 more source

Sperm head morphology is associated with sperm swimming speed: A comparative study of songbirds using electron microscopy

Evolution; international journal of organic evolution, 2018
Sperm exhibit extraordinary levels of morphological diversification across the animal kingdom. In songbirds, sperm have a helically shaped head incorporating a distinct acrosomal membrane or “helical keel,” the form and extent of which varies across ...
H. N. Støstad, A. Johnsen, J. Lifjeld, Melissah Rowe   +3 more
semanticscholar   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Mitochondria directly influence fertilisation outcome in the pig [PDF]

, 2006
The mitochondrion is explicitly involved in cytoplasmic regulation and is the cell's major generator of ATP. Our aim was to determine whether mitochondria alone could influence fertilisation outcome.
Abeydeera, Alves, Anderson, Barritt, Barritt, Barritt, Blok, Brenner, Cetica, Clayton, Cohen, Cohen, Cran, de Loos, Downs, Dumollard, Eisen, Emma C Spikings, Findlay, Fong, Hue, Jansen, Justin C St John, King, Koo, Krakauer, Larsson, Larsson, Li, Lin, Liu, Mach  ty, Marchington, Mariana Freitas, Marinos, McConnell, Michaels, Moyes, Park, Pik  , Poulton, Raghu, Reynier, Roca, Sathananthan, Shahinaz H El Shourbagy, Shea, Spelbrink, St John, St John, St John, St John, St. John, Stojkovic, Sun, Tessa, Tian, Trimarchi, Ursing, Van Blerkom, Van Blerkom, Van Blerkom, Wakayama, Wallace, Wilmut, Zamzami, Zernicka-Goetz   +66 more
core   +3 more sources

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Correlation between Sperm Motility and Morphology in the Success Rate of in Vitro Fertilization Procedure

Althea Medical Journal, 2016
Background: In vitro fertilization (IVF) is one of the assisted reproductive technology that has been used in treating infertility. Unfortunately, not every IVF procedure achieves 100% success in fertilizing the oocyte.
Praditya Virza Ramadhan, Andri Rezano, Wiryawan Permadi   +2 more
doaj   +1 more source