Results 81 to 90 of about 216,508 (311)
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, EarlyView.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
In vitro evaluation of sperm quality
Animal Reproduction Science, 2008 This paper highlights selected laboratory analyses that are currently used to evaluate sperm, and describes why results from these assays do not consistently correlate with sperm fertility. Reasons for the disconnect between the two are due in part to the definition and reliability of the fertility data collected, to the complexity of the spermatozoon ...
Mocé, Eva, Graham, James K.
openaire +3 more sources
Testicular cancer and sperm DNA damage: short- and long-term effects of antineoplastic treatment [PDF]
, 2015 The aim of this study was to investigate sperm DNA damage induced by chemo- and radiotherapy in patients with testicular cancer to provide data on the extent and persistence of nuclear damage that might affect individual reproductive potential.
F. Rizzo +7 more
core +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Superior sperm competitors sire higher–quality young [PDF]
Proceedings of the Royal Society of London. Series B: Biological Sciences, 2003 The evolution of polyandry remains controversial. This is because, unlike males, in many cases multiple mating by females does not increase fecundity and inevitably involves some costs. As a result, a large number of indirect benefit models have been proposed to explain polyandry.
Hosken, D.J. +4 more
openaire +3 more sources
Animal, 2014 Cholesterol-loaded cyclodextrins (CLC) added to the sperm before cryopreservation enhance sperm quality after freeze-thawing in several cold shock-sensitive species, including cattle and goats.
E. Mocé +3 more
doaj +1 more source
Pulmonary exposure to carbonaceous nanomaterials and sperm quality [PDF]
, 2018 Background Semen quality parameters are potentially affected by nanomaterials in several ways: Inhaled nanosized particles are potent inducers of pulmonary inflammation, leading to the release of inflammatory mediators.
Christensen, Preben +5 more
core +3 more sources
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Home sperm testing device versus laboratory sperm quality analyzer: comparison of motile sperm concentration [PDF]
Fertility and Sterility, 2018 To test the ability of the smartphone-based YO Home Sperm Test to accurately and precisely measure motile sperm concentration (MSC) versus the SQA-Vision, an automated laboratory semen analyzer.MSC compared for the YO device on Galaxy and iPhone smartphones versus the SQA-Vision in a double-blind manner.Academic medical center.Donor semen samples from ...
Ashok Agarwal +6 more
openaire +2 more sources