Results 101 to 110 of about 31,775 (244)

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse [PDF]

, 2016
Spermiogenesis is the differentiation of spermatids into motile sperm consisting of a head and a tail. The head harbors a condensed elongated nucleus partially covered by the acrosome-acroplaxome complex.
Berbari, Nicolas F., Kesterson, Robert A., Kierszenbaum, Abraham L., Malarkey, Erik, Pasek, Raymond C., Sharma, Neeraj, Tres, Laura L., Yoder, Bradley K.   +7 more
core   +1 more source

Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda, Haruhiko Miyata, Masahito Ikawa   +2 more
wiley   +1 more source

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

Andrology, EarlyView.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik, Jessica M. Snyder, Haley A. Martin, John K. Amory   +3 more
wiley   +1 more source

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
A. Monteiro, Abel, Baker, Baker, Baker, Bartles, Beardsley, Boettger-Tong, Carpenter, Casteren, Cattanach, Chang, Cheng, Czechowski, De Gendt, De Gendt, Denolet, Dierich, Dym, Eacker, F. Guillou, G. Verhoeven, H. M. Charlton, Haavisto, Haywood, Heckert, Hirst, Hofmann, Holdcraft, Johnston, Jonsson, K. De Gendt, Kageyama, Kumar, Lecureuil, Lyon, M. H. Abel, Maguire, Mayhew, McLachlan, McLachlan, Meng, O’Shaughnessy, O’Shaughnessy, O’Shaughnessy, O’Shaughnessy, O’Shaughnessy, O’Shaughnessy, P. J. Baker, P. J. O’Shaughnessy, Russell, Russell, Sadate-Ngatchou, Sadate-Ngatchou, Safina, Sharpe, Singh, Sluka, Tan, Vihko, Wong, Wreford, Yang, Zhou   +63 more
core   +2 more sources

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

STRESS CAN UNDERMINE THE PROCESS OF SPERMATOGENESIS IN MICE

Jurnal Ners, 2017
Introduction: This study aimed to determine the effect of stress on the process of spermatogenesis and testosterone levels of mice (Mus musculus) male. Method: This was an experimental study using a completely randomized design.
Yuni Sufyanti Arief
doaj   +1 more source

The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process [PDF]

, 2006
Caspase family proteases play important roles in the regulation of apoptotic cell death. Initiator caspases are activated in response to death stimuli, and they transduce and amplify these signals by cleaving and thereby activating effector caspases.
Baehrecke, Eric H., Berry, Deborah L., Chen, Chun Hong, Guo, Ming, Hay, Bruce A., Huang, Haixia, Huh, Jun R., Muro, Israel, Yoo, Soon Ji   +8 more
core   +2 more sources

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

The role of Merlin in spermatogenesis [PDF]

, 2008
Background Drosophila Merlin, the homolog of the human Neurofibromatosis 2 (NF2) gene, is important for the regulation of cell proliferation and receptor endocytosis. Male flies carrying a Mer3 allele, a missense mutation (Met177→Ile) in the Merlin gene,
Omelyanchuk Leonid V, Gubanova Natalia V, Yudina Olga S, Kopyl Sergei A, Akhmametyeva Elena M, Dorogova Natalia V, Chang Long-Sheng   +6 more
core   +1 more source