Results 131 to 140 of about 26,767 (249)

Potentially Toxic Elements and Male Reproductive Toxicity: Mechanisms, Implications, and Protective Strategies: A Narrative Review

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Potentially toxic elements impair male reproductive function through oxidative stress, DNA damage, mitochondrial dysfunction, inflammation, endocrine disruption and epigenetic alterations. Antioxidants, phytochemicals, chelating agents and healthy lifestyle interventions may help mitigate testicular toxicity and preserve fertility.
Sakshi Yadav, Placheril J John
wiley   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, Volume 14, Issue 7, Page 2150-2159, October 2026.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Compromised MDC1 and γH2AX signal expansion in Mof deleted pachytene spermatocytes.

, 2018
A. Immunofluorescence with SYCP3 (red) and BRCA1 (green) antibodies in control and Mof cKO spermatocytes. Scale bars, 10 μm. B. Immunofluorescence with SYCP3 (red) and ATR (green) antibodies in control and Mof cKO spermatocytes. Scale bars, 10 μm. C. The
Qinghua Shi (169845), Peng Xu (17962), Liangwen Zhong (352328), Hanwei Jiang (5278040), Xiaoling Sun (307925), Xiaohua Jiang (177009), Hui Fang (177012), Wei Zheng (25452), Qian Gao (146991), Qiaomei Hao (169840), Asim Ali (4489621), Teka Khan (5278037), Liu Wang (213066), Shi Yin (1288620), Tej K. Pandita (687457)   +14 more
core   +1 more source

Chromosome Aberrations in Mouse Spermatocytes and Oocytes Exposed to 300R ϒ-Radiation: A Comparison

, 1973
It has been repeatedly demonstrated that radiation induces chromosome aberrations in mouse oocytes and spermatocytes. However, the results of previous studies, in which the frequency of aberrations recovered from irradiated oocytes and spermatocytes were
Tsuchida, Shigeru William
core   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, Volume 14, Issue 7, Page 2329-2346, October 2026.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Sub-nuclear localisation of Pc, the tTAF Sa and elongating RNA polymerase II in primary spermatocytes.

, 2013
(A–H) Pc-GFP in live (A–D) and fixed immunolabelled (E–H) primary spermatocytes showing representative z sections of very early (A,E), early (B,F), mid (C,G) and mature (D,H) spermatocytes.
Robert A. H. White (254756), Juliet Redhouse (473476), Sherif El-Sharnouby (473475)   +2 more
core   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, Volume 14, Issue 7, Page 1962-1970, October 2026.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

P15 | PHB/JAK/H3Y41PH AXIS REGULATES MEIOTIC RECOMBINATION IN SPERMATOGENESIS

European Journal of Histochemistry
Previously, we have shown that human sperm Prohibitin (PHB) expression is significantly negatively correlated with mitochondrial ROS levels but positively correlated with mitochondrial membrane potential and motility.
doaj   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Homologous chromosomes pair normally and achieve initial synapsis in Hfm1^−/− spermatocytes.

, 2013
(a) Immunostaining of SYCP3 in wild-type and Hfm1−/− spermatocytes. Examples of pachytene-like spermatocytes are shown. Arrows mark sites of synaptic defects. XY and X-Y indicate positions of tightly and loosely associated sex chromosomes, respectively. (
Joseph L. Wilkerson (392634), Michel F. Guiraldelli (155116), Michael E. Dresser (162092), Craig Eyster (392633), Roberto J. Pezza (155142)   +4 more
core   +1 more source