Results 1 to 10 of about 7,752 (208)

BRCA1 preserves genome integrity during the formation of undifferentiated spermatogonia

EMBO Reports
Undifferentiated spermatogonia, which form shortly after birth, consist of spermatogonial stem cells and progenitor spermatogonia that maintain homeostasis.
Peng Li, Yidan Liu, Lin-Yu Lu
exaly   +3 more sources

In Vitro Cytotoxicity Effects of Zinc Oxide Nanoparticles on Spermatogonia Cells

Cells, 2020
Zinc Oxide Nanoparticles (ZnO NPs) are a type of metal oxide nanoparticle with an extensive use in biomedicine. Several studies have focused on the biosafety of ZnO NPs, since their size and surface area favor entrance and accumulation in the body, which
Maria de Lourdes Pereira, Ana Rita Pinho, Filipa Martins   +2 more
exaly   +3 more sources

Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor [PDF]

PLoS Genetics, 2015
All-trans retinoic acid (ATRA) is instrumental to male germ cell differentiation, but its mechanism of action remains elusive. To address this question, we have analyzed the phenotypes of mice lacking, in spermatogonia, all rexinoid receptors (RXRA, RXRB
Manuel Mark, Gérard Benoit, Nadege Vernet   +2 more
exaly   +2 more sources

Targeted Gene Editing in Porcine Spermatogonia [PDF]

Frontiers in Genetics, 2021
To study the pathophysiology of human diseases, develop innovative treatments, and refine approaches for regenerative medicine require appropriate preclinical models.
Dennis Webster, Alla Bondareva, Staci Solin, Taylor Goldsmith, Lin Su, Nathalia de Lima e Martins Lara, Daniel F. Carlson, Ina Dobrinski   +7 more
doaj   +3 more sources

Effect of honey bee venom on the histological changes of testes and hormonal disturbance in diabetic mice [PDF]

Veterinary World, 2022
Background and Aim: Hyperglycemia associated with hyper- or hypo-insulinemia is a hallmark of type 2 diabetes mellitus, which is firmly linked to decreased male infertility.
Sattar J. J. AL-Shaeli, Talal Jabal Hussen, Ali M. Ethaeb   +2 more
doaj   +1 more source

Overexpression of lncRNA-Gm2044 in spermatogonia impairs spermatogenesis in partial seminiferous tubules

Poultry Science, 2022
: Long noncoding RNAs (lncRNAs) have been demonstrated to regulate reproduction in mammals. Our previous study revealed that the expression level of lncRNA-Gm2044 was obviously elevated in nonobstructive azoospermia with spermatogonial arrest.
Ke Hu, Yuanyuan Gao, Yifan Xu, Chaofan He, Kaixian Wang, Leina Li, Yaping Liao, Xiaohua Liu, Meng Liang   +8 more
doaj   +1 more source

Micro RNA in Semen/Urine from Non-Obstructive Azoospermia Patients as Biomarkers to Predict the Presence of Testicular Spermatozoa and Spermatogonia

Life, 2023
About half of testicular sperm extraction (TESE) procedures in men with non-obstructive azoospermia (NOA), including men with Klinefelter syndrome (KS), are unsuccessful. To avoid unnecessary invasive surgery, biomarkers for spermatozoa were studied.
Margo Willems, Céline Devriendt, Catharina Olsen, Ben Caljon, Toon Janssen, Inge Gies, Veerle Vloeberghs, Herman Tournaye, Dorien Van Saen, Ellen Goossens   +9 more
doaj   +1 more source

EFFECT OF DICHLORVOS PESTICIDE ON FERTILITY OF LABORATORY MALE MICE (Mus musculus L.) [PDF]

Basrah Journal of Veterinary Research, 2008
Dichlorvos is one of organophosphate insect pesticides which is widely distributed in environment. This study deals with the effect of this pesticide on sperms number , sperm abnormalities and spermatogenesis in laboratory male mice (Mus musculus L ...
Faris Shaker Kata
doaj   +1 more source

Spermatogonial Gene Networks Selectively Couple to Glutathione and Pentose Phosphate Metabolism but Not Cysteine Biosynthesis

iScience, 2021
Summary: In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogonial
David Prokai, Ashutosh Pudasaini, Mohammed Kanchwala, Andrew T. Moehlman, Alexandrea E. Waits, Karen M. Chapman, Jaideep Chaudhary, Jesus Acevedo, Patrick Keller, Xing Chao, Bruce R. Carr, F. Kent Hamra   +11 more
doaj   +1 more source

RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3

The Journal of Reproduction and Development, 2020
PTBP1, a well-conserved RNA-binding protein, regulates cellular development by tuning posttranscriptional mRNA modification such as alternative splicing (AS) or mRNA stabilization. We previously revealed that the loss of Ptbp1 in spermatogonia causes the
Manami SENOO, Hiroshi HOZOJI, Yu ISHIKAWA-YAMAUCHI, Takashi TAKIJIRI, Sho OHTA, Tomoyo UKAI, Mio KABATA, Takuya YAMAMOTO, Yasuhiro YAMADA, Masahito IKAWA, Manabu OZAWA   +10 more
doaj   +1 more source