BRCA1 preserves genome integrity during the formation of undifferentiated spermatogonia [PDF]
EMBO ReportsUndifferentiated spermatogonia, which form shortly after birth, consist of spermatogonial stem cells and progenitor spermatogonia that maintain homeostasis.
Peng Li, Yidan Liu, Lin-Yu Lu
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Doxorubicin and 4-Hydroperoxycyclophosphamide Alter Mitochondrial Dynamics and miR-34 Expression in Spermatogonia and Spermatocytes In Vitro. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Doxorubicin (DOX) and cyclophosphamide (CP) are widely used chemotherapeutic agents with known gonadotoxic effects. Since miRNAs play a key role in the transcriptional regulation of spermatogenesis, they are suggested as biomarkers for male infertility.
Öztatlıcı H +4 more
europepmc +4 more sources
Advanced Science, EarlyView.This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He +14 more
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Cell Proliferation, 1985 AbstractIn the seminiferous epithelium the differentiating spermatogonia proliferate following a very strict synchronous pattern, and undergo the S phase during parts of particular epithelial stages. the undifferentiated spermatogonia do not divide synchronously and display maximum proliferative activity in stages XI‐III.
de rooij, D. G., Lok, D., Weenk, D.
openaire +4 more sources
Life, 2023 About half of testicular sperm extraction (TESE) procedures in men with non-obstructive azoospermia (NOA), including men with Klinefelter syndrome (KS), are unsuccessful. To avoid unnecessary invasive surgery, biomarkers for spermatozoa were studied.
Margo Willems +2 more
exaly +3 more sources
BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: Spermatogenesis is sustained by the homeostasis of self-renewal and differentiation of undifferentiated spermatogonia throughout life, which is regulated by transcriptional and posttranscriptional mechanisms.
Ruiqi Liu +10 more
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Targeted Gene Editing in Porcine Spermatogonia [PDF]
Frontiers in Genetics, 2021 To study the pathophysiology of human diseases, develop innovative treatments, and refine approaches for regenerative medicine require appropriate preclinical models.
Dennis Webster +7 more
doaj +3 more sources
Set7-Mediated Repression of the HIF-1α Adaptive Response Triggers Apoptosis in Hypoxic Spermatogonia [PDF]
Frontiers in Bioscience-LandmarkBackground:Male infertility, often caused by oligospermia, is a major global health concern. Hypoxia is a known inducer of germ cell death, a process governed by the hypoxia-inducible factor 1α (HIF-1α).
Yangyang Song +3 more
doaj +2 more sources
JMJD3 Deficiency Alters H3K27me3 Landscapes and Adhesion-Related Transcriptional Programs in Aged Spermatogonia. [PDF]
Mol Reprod DevSakurai Y +7 more
europepmc +3 more sources
Super-Multiplexed Label-Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation. [PDF]
Adv Sci (Weinh)Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Li J +23 more
europepmc +2 more sources