Results 31 to 40 of about 17,684 (208)
Cells, 2020 Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions.
Harald Welter +8 more
doaj +1 more source
Isolation and characterization of human spermatogonial stem cells
Reproductive Biology and Endocrinology, 2011 Background To isolate and characterization of human spermatogonial stem cells from stem spermatogonium. Methods The disassociation of spermatogonial stem cells (SSCs) were performed using enzymatic digestion of type I collagenase and trypsin.
Liu Shixue +3 more
doaj +1 more source
The Journal of Reproduction and Development, 2023 Spermatogonial stem cells (SSCs) possess a unique ability to recolonize the seminiferous tubules. Upon microinjection into the adluminal compartment of the seminiferous tubules, SSCs transmigrate through the blood-testis barrier (BTB) to the basal ...
Hiroko MORIMOTO +2 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Image-based identification and quantification of different types of spermatogenic cells is of great importance, not only for reproductive studies but also for genetic breeding.
Ding Ye +6 more
doaj +1 more source
Cell Proliferation, 1985 AbstractIn the seminiferous epithelium the differentiating spermatogonia proliferate following a very strict synchronous pattern, and undergo the S phase during parts of particular epithelial stages. the undifferentiated spermatogonia do not divide synchronously and display maximum proliferative activity in stages XI‐III.
de rooij, D. G., Lok, D., Weenk, D.
openaire +3 more sources
BRCA1 preserves genome integrity during the formation of undifferentiated spermatogonia
EMBO ReportsUndifferentiated spermatogonia, which form shortly after birth, consist of spermatogonial stem cells and progenitor spermatogonia that maintain homeostasis.
Peng Li +6 more
doaj +1 more source
Organotypic Rat Testicular Organoids for the Study of Testicular Maturation and Toxicology
Frontiers in Endocrinology, 2022 An in vitro system to study testicular maturation in rats, an important model organism for reproductive toxicity, could serve as a platform for high-throughput drug and toxicity screening in a tissue specific context. In vitro maturation of somatic cells
Sadman Sakib +6 more
doaj +1 more source
Spermatogonia: stem cells with a great perspective [PDF]
Reproduction, 2001 Abstract Interest in spermatogonia has grown in recent years as a result of exciting developments in stem cell research in general and the development of new research tools allowing the isolation, culture and transplantation of these cells. This review focuses on the methodological breakthroughs and highlights the recent findings that
S, Meachem +2 more
openaire +2 more sources
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source