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The progression of spermatogenesis relies on the precise regulation of spermatogonial self-renewal and differentiation. Many genes/proteins have been identified with specific expression profiles in individual spermatogonial cell types but the molecular mechanism of their regulation is still obscure.
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Cell Cycle of Spermatogonia in Mouse Testis [PDF]
This report measures the spermatogonial cell cycles and their constituent phases of proliferating type A, intermediate (In), and type B cells in the testis of the young mouse, and analyzes the cell cycle and cell population kinetic parameters, such as growth fractions and cell-birth rates, from /sup 3/HTdR autoradiographic data.
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Ultrastructure of the Bovine Testis in Cattle (Bos taurus): New View
The purpose of this study was to analyze the ultrastructure of the testes of sexually immature calves and reproductive bulls of the Polish Holstein-Friesian Black-and-White breed. Utilizing TEM, this study identified three distinct stages of seminiferous
Katarzyna Michałek +7 more
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Geminin is required for mitotic proliferation of spermatogonia
Spermatogonial stem cells divide throughout life, maintaining their own population and giving rise to differentiated gametes. The unstable regulatory protein Geminin is thought to be one of the factors that determine whether stem cells continue to divide or terminally differentiate.
Barry, Kelly A. +3 more
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Cyclic events of spermatogenic cells in the seminiferous tubules of Guinea pigs
There are twelve stages were identified in the spermatogenic cycle in Guinea Pig, each contains one or two generations of spermatids which is connected with one or two generations of Spermatocytes and one or two generations of spermatogonia.
Abdul-Hadi S. Mohammed, Widad A. Jawad
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Busulfan Chemotherapy Downregulates TAF7/TNF-α Signaling in Male Germ Cell Dysfunction
Background: Busulfan is an FDA-approved alkylating drug used in the chemotherapy of advanced acute myeloid leukemia. The precise mechanisms by which Busulfan kills spermatogonia stem cells (SSCs) are not yet completely understood. Methods: Using a murine
Daoyuan Huang +4 more
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Methods to quantify germ cell number in human immature testicular tissues are essential to evaluate the impact of chemotherapy exposures and to optimise cryopreservation protocols used in fertility preservation for prepubertal boys.
Emma Kearney +8 more
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Simple Classification of Male Mouse Germ Cells using Hoechst 33258 Staining
In the study for a differentiation and development of spermatogonial cells, the researchers should commonly require a simple, fast and reasonable method that could evaluate the developmental stage of male germ cells without any damage and also ...
Kyoung Guk Kim, Young Sik Park
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Objective: To analyze the difference in the number of spermatogonia, leydig cells and sertoli cells in young age of white mice Wistar strain after inhalation of chronic nicotine exposure.
Aril Rizaldi +2 more
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Animal modeling methods for oligospermia: A review
Oligospermia, characterized by a low sperm count in semen, is a major cause of male infertility and may result from various factors including infections, lifestyle choices, retrograde ejaculation, tumors, hormonal imbalances, drug treatments, and ...
Dinesh Sharma +7 more
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