Results 61 to 70 of about 25,438 (286)

Spermatogonia Differentiation Requires Retinoic Acid Receptor γ

, 2012
International audienceVitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three nuclear receptor isotypes, RA receptor (RAR)α (RARA), RARβ, and RARγ ...
Mathilde Raverdeau, Shosei Yoshida, Betty Feret, Klopfenstein, Muriel, Dennefeld, Christine, Féret, Betty, Ghyselinck, Norbert, B., Muriel Klopfenstein, Mark, Manuel, Catherine Célébi, Norbert B. Ghyselinck, Gely-Pernot, Aurore, Celebi, Catherine, Raverdeau, Mathilde, Ghyselinck, Norbert,, Christine Dennefeld, Yoshida, Shosei, Manuel Mark, Aurore Gely-Pernot   +18 more
core   +1 more source

In vitro propagation of XXY human Klinefelter spermatogonial stem cells: A step towards new fertility opportunities

Frontiers in Endocrinology, 2022
Klinefelter Syndrome (KS) is characterized by a masculine phenotype, supernumerary sex chromosomes (47, XXY), and impaired fertility due to loss of spermatogonial stem cells (SSCs).
Guillermo Galdon, Guillermo Galdon, Nicholas A. Deebel, Nicholas A. Deebel, Nima Pourhabibi Zarandi, Darren Teramoto, YanHe Lue, Christina Wang, Ronald Swerdloff, Mark J. Pettenati, William G. Kearns, Stuart Howards, Stanley Kogan, Stanley Kogan, Anthony Atala, Anthony Atala, Hooman Sadri-Ardekani, Hooman Sadri-Ardekani   +17 more
doaj   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Isolation and characterization of Kit-positive Spermatogonia.

, 2013
A) Germ cells were obtained with sequential enzymatic digestions from testis of 7dpp animals and analyzed by FACS analysis for Kit expression (left panel).
Manuela Pellegrini (367290), Giuseppina Claps (367291), Sara Di Siena (276168), Raffaele Geremia (318560), Pellegrino Rossi (367294), Silvia Di Cesare (367292), Paola Grimaldi (276175), Susanna Dolci (367293)   +7 more
core   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Isolation and Characterization of Highly Pure Type A Spermatogonia From Sterlet (Acipenser ruthenus) Using Flow-Cytometric Cell Sorting

Frontiers in Cell and Developmental Biology, 2021
Sturgeons are among the most ancient linages of actinopterygians. At present, many sturgeon species are critically endangered. Surrogate production could be used as an affordable and a time-efficient method for endangered sturgeons. Our study established
Xuan Xie, Tomáš Tichopád, Galina Kislik, Lucie Langerová, Pavel Abaffy, Radek Šindelka, Roman Franěk, Michaela Fučíková, Christoph Steinbach, Mujahid Ali Shah, Ivo Šauman, Ivo Šauman, Fan Chen, Martin Pšenička   +13 more
doaj   +1 more source

Characterisation of isolated gonocyte and spermatogonia cells.

, 2012
Haematoxylin and eosin stained two day old testis section (1A) demonstrates that gonocytes are found in the centre of the seminiferous tubules of mice.
Skye C. McIver (170151), Danielle M. Santarelli (170167), Brett Nixon (117179), Shaun D. Roman (170175), Simone J. Stanger (170159), Eileen A. McLaughlin (116618)   +5 more
core   +1 more source

Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice

Stem Cell Reports, 2017
The introduction of megabase-sized large DNA fragments into the germline has been a difficult task. Although microcell-mediated chromosome transfer into mouse embryonic stem cells (ESCs) allows the production of transchromosomic mice, ESCs have unstable ...
Takashi Shinohara, Kanako Kazuki, Narumi Ogonuki, Hiroko Morimoto, Shogo Matoba, Kei Hiramatsu, Kazuhisa Honma, Teruhiko Suzuki, Takahiko Hara, Atsuo Ogura, Mitsuo Oshimura, Mito Kanatsu-Shinohara, Yasuhiro Kazuki   +12 more
doaj   +1 more source

Male reproductive system in stenopodidean shrimps: Unveiling basal reproductive traits in shrimp‐like Pleocyemata (Stenopodidae and Spongicolidae)

The Anatomical Record, EarlyView.
Abstract Stenopodidea represents one of the basal lineages within Pleocyemata, yet the male reproductive system (MRS) of this group remains poorly understood, with limited information available regarding its morphology and function. This study provides the first detailed description of the MRS in four stenopodidean shrimp species from two families ...
Caio Santos Nogueira, Lucas Rezende Penido Paschoal, Fernando José Zara   +2 more
wiley   +1 more source

Effect of Vasectomy on the Testosterone Levels and Testicular Structures in Bucks for Long Term [PDF]

The Iranian Journal of Veterinary Science and Technology
This study was conducted on 12 adults local crossbreed Bucks to investigate the long-term effect of the vasectomy on Testosterone levels, sexual efficiency, and testicular structures.
Dhurghamh alhaideri, Hussein Ibraheim
doaj   +1 more source