Results 11 to 20 of about 26,767 (249)
Alterations in chromosomal synapses and DNA repair in apoptotic spermatocytes of Mus m. domesticus [PDF]
European Journal of Histochemistry, 2016 We investigated whether apoptotic spermatocytes from the mouse Mus m. domesticus presented alterations in chromosomal synapses and DNA repair. To enrich for apoptotic spermatocytes, the scrotum’s temperature was raised by partially exposing animals for ...
E. Ayarza +5 more
doaj +4 more sources
TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes. [PDF]
PLoS Genetics, 2017 Tudor containing protein 6 (TDRD6) is a male germ line-specific protein essential for chromatoid body (ChB) structure, elongated spermatid development and male fertility.
Müge Akpınar +6 more
doaj +2 more sources
WFS1 Deficiency Impairs PIAS4-Associated SUMOylation and Increases Ubiquitin-Mediated Spermatogenesis-Related Protein Degradation Leading to Testicular Male Infertility. [PDF]
Adv Sci (Weinh)The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Tian Y +14 more
europepmc +2 more sources
BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells. [PDF]
Adv Sci (Weinh)BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Li X +8 more
europepmc +2 more sources
International Journal of Molecular Sciences, 2023 Spermatocytic tumor (ST) is a very rare disease, accounting for approximately 1% of testicular cancers. Previously classified as spermatocytic seminoma, it is currently classified within the non-germ neoplasia in-situ-derived tumors and has different clinical-pathologic features when compared with other forms of germ cell tumors (GCTs).
Simona Secondino +8 more
openaire +2 more sources
Archives of Pathology & Laboratory Medicine, 2009 Abstract Spermatocytic seminoma is a rare germ cell tumor distinct from classical seminoma, both clinically and pathologically. It affects older men, has not been associated with a history of cryptorchidism, and has no known counterpart in ovary or any other site.
Nidhi, Aggarwal, Anil V, Parwani
openaire +2 more sources
Chromosome movements in locust spermatocytes [PDF]
, 2007 We tested whether the mechanisms of chromosome movement during anaphase in locust [Locusta migratoria (L.)] spermatocytes might be similar to those described in crane-fly spermatocytes. Actin and myosin have been implicated in anaphase
Forer, Arthur, Fabian, Lacramioara
core +1 more source
Igsf11 deficient mouse spermatocytes develop beyond pachytene checkpoint.
, 2021 (A) Comparison of the axial element assembly in spermatocytes of the control (Igsf11+/-) and mutant (Igsf11-/-) mice using SYCP3 and REC8 as markers. (B) Meiotic progression analysis of the first wave spermatocytes with the VPHS transgenic reporter.
Gengzhen Zhu (10066444) +8 more
core +1 more source
WNK1 is required during male pachynema to sustain fertility
iScience, 2023 Summary: WNK1 is an important regulator in many physiological functions, yet its role in male reproduction is unexplored. In the male germline, WNK1 is upregulated in preleptotene spermatocytes indicating possible function(s) in spermatogenic meiosis ...
Ru-pin Alicia Chi +11 more
doaj +1 more source
Cohesin SMC1β promotes closed chromatin and controls TERRA expression at spermatocyte telomeres
Life Science Alliance, 2023 Cohesin SMC1β; ensures silencing at chromosome ends, restricts TERRA expression and RNA-DNA hybrid formation, and prevents telomer damage. Previous data showed that meiotic cohesin SMC1β protects spermatocyte telomeres from damage. The underlying reason,
Uddipta Biswas +5 more
doaj +1 more source