Results 51 to 60 of about 38,921 (268)

Doxorubicin Affects Testicular Lipids with Long-Chain (C18-C22) and Very Long-Chain (C24-C32) Polyunsaturated Fatty Acids [PDF]

, 2007
Doxorubicin disrupts spermatogenesis by causing apoptosis of spermatogonia and primary spermatocytes. The aim of this study was to examine the effect of this agent on adult rat testicular lipids and their fatty acids.
Aveldaño, Marta Isabel, Maldonado, Eduardo N., Zanetti, Samanta Romina   +2 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Mouse tafazzin is required for male germ cell meiosis and spermatogenesis [PDF]

, 2015
Barth syndrome is an X-linked mitochondrial disease, symptoms of which include neutropenia and cardiac myopathy. These symptoms are the most significant clinical consequences of a disease, which is increasingly recognised to have a variable presentation.
Bryson, S., Cadalbert, L.C., Ghaffar, F.N., Gottlieb, E., Stevenson, D., Strathdee, D., Vaz, F.M.   +6 more
core   +7 more sources

Hybridisation generates a hopeful monster: a hermaphroditic selfing cichlid [PDF]

, 2016
Compared to other phylogenetic groups, self-fertilization (selfing) is exceedingly rare in vertebrates and is known to occur only in one small clade of fishes.
Garcia-Alonso, Javier, Smith, Alan, Svensson, Ola, Van Oosterhout, Cock   +3 more
core   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

Adverse effects of bisphenol A on the testicular parenchyma of zebrafish revealed using histomorphological methods

Veterinární Medicína, 2016
The purpose of this study was to evaluate the consequences of bisphenol A (BPA) exposure in zebrafish (Danio rerio). Short-term effects at a testes level were assessed by means of different biomarkers in 60 male zebrafish exposed for 14 days in aquariums
A.J. Lora, A.M. Molina, C. Bellido, A. Blanco, J.G. Monterde, M.R. Moyano   +5 more
doaj   +1 more source

TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes. [PDF]

PLoS Genetics, 2017
Tudor containing protein 6 (TDRD6) is a male germ line-specific protein essential for chromatoid body (ChB) structure, elongated spermatid development and male fertility.
Müge Akpınar, Mathias Lesche, Grigorios Fanourgakis, Jun Fu, Konstantinos Anastassiadis, Andreas Dahl, Rolf Jessberger   +6 more
doaj   +1 more source

Meta‐GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammalian Fertility

Advanced Science, EarlyView.
This study incorporated 14 210 individuals to perform a GWAS meta‐analysis of six semen quality traits. The GWAS meta‐analysis identifies 234 GWAS loci associated with semen quality traits. The incorporation with a functional genomics resource explains potential genetic regulation of ∼40% GWAS signals underlying semen quality traits.
Qing Lin, Xiaodian Cai, Zhanming Zhong, Tingting Li, Xinyou Chen, Wondossen Ayalew, Zhiting Xu, Chen Wei, Xiaoke Zhang, Hong Cheng, Zhenyang Zhang, Xuehua Li, Yongjie Tang, Siqian Chen, Jun Zhou, Jinglei Si, Xibo Wu, Chao Ning, Qishan Wang, Yuchun Pan, Yahui Gao, Jiaqi Li, Ying Yu, Zhe Zhang, Yunxiang Zhao, Lingzhao Fang, Zhe Zhang   +26 more
wiley   +1 more source

Testing of mitosis and meiosis in female and male gametes

Андрология и генитальная хирургия, 2017
Method of quantitative evaluation of the immature germ cells, their pathology in mitosis and meiosis (in semen, embryo and fetal ovaries, of gonad biopsies or fragments of sectioned material) is informative method and should be introduced into the ...
L. F. Kurilo, S. Sh. Khayat
doaj   +1 more source

Defects in Meiotic Recombination Delay Progression Through Pachytene in Tex19.1-/- Mouse Spermatocytes [PDF]

, 2018
Recombination, synapsis, chromosome segregation and gene expression are co-ordinately regulated during meiosis to ensure successful execution of this specialised cell division.
A Chicheportiche, A Copsey, AH Peters, AM Lyndaker, B Drabent, CA Adelman, CK Cahoon, David Read, E Bolcun-Filas, E Meijering, E Testa, EA Ahmed, EF Joyce, F Baudat, F Baudat, F Carofiglio, F Yang, H Nakata, HBDP Rao, I Roig, Ian R. Adams, J Chen, J Cobb, J Reichmann, J Reichmann, J Schindelin, JA Hackett, James H. Crichton, JH Crichton, JH Crichton, JH Lammers, JM Cloutier, JMA Turner, JY An, K Daniel, L Kauppi, L Kauppi, L Wojtasz, L Wojtasz, L Xu, L-Y Lu, LH Hartwell, LK Anderson, M Barchi, M Faieta, M Fujimuro, M MacLennan, M Marcet-Ortega, N Reynolds, NM Vranis, PB Moens, PJ Romanienko, PJ Wang, PM Carlton, PS Burgoyne, R Core Team, R Öllinger, RL Meuwissen, S Kuntz, S Pacheco, S Schoenmakers, SK Mahadevaiah, SK Mahadevaiah, TJ Broering, VD Rinaldi, VV Subramanian, WM Baarends, XC Li, Y Costa, Y Tarabay, Y-H Shin, YT Kwon   +71 more
core   +1 more source