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The Potential Role of Deubiquitinating Enzymes (DUBs) in Male Fertility [PDF]
BiomoleculesUbiquitination dynamically regulates critical cellular processes, including cell cycle progression, apoptosis, DNA repair, and chromatin remodeling. Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and are equally important for ...
Jung Min Kim
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Reverse transcriptase inhibitors enable the generation of fertile spermatids from fetal mouse testes in vitro [PDF]
Communications BiologyOrgan culture systems enabling in vitro spermatogenesis from neonatal mouse testes exist, but differentiation from fetal testes shortly after sex determination remains unsuccessful.
Mayuka Nishida +11 more
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Current Biology, 2017 Most organisms consist of two cell lineages - somatic cells and germ cells. The former are required for the current generation, and the latter create offspring. Male and female germ cells are usually produced during spermatogenesis and oogenesis, which take place in the testis and the ovary, respectively. Spermatogenesis involves the differentiation of
Hitoshi, Nishimura, Steven W, L'Hernault
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WormBook, 2006 Spermatogenesis creates functional sperm from an initially undifferentiated germ cell. In the nematode Caenorhabditis elegans, both males and hermaphrodites engage in spermatogenesis. The hermaphrodite germ line, like that of the male, initiates spermatogenesis during the L4 larval stage.
Eitetsu, Koh, Jin, Choi, Mikio, Namiki
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Advances in research on RNA N-6-methyladenosine(m6A) modification related enzymes in mammalian spermatogenesis [PDF]
Jichu yixue yu linchuang, 2023 N-6-methyladenosine(m6A) has been well-known to be a type of RNA epigenetic modification over the past decade. The m6A modification enzymes include “Writers” (METTL3/14/WTAP, etc.),“Erasers” (FTO and ALKBH5) and “Readers” (YTHDC1/2,YTHDF1/2/3, etc ...
ZHANG Qiang, SU Wenhui
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Human Reproduction, 1998 Spermatogenesis is a complex process involving mitotic cell division, meiosis and the process of spermiogenesis. The regulation of spermatogenesis involves both endocrine and paracrine mechanisms. The endocrine stimulation of spermatogenesis involves both follicle stimulating hormone (FSH) and luteinizing hormone, the latter acting through the ...
D M, de Kretser +4 more
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Cells, 2022 Spermatogenesis is a complex process occurring in mammalian testes, and constant sperm production depends on the exact regulation of the microenvironment in the testes.
Yu Zhou, Yunyan Wang
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Functions of somatic cells for spermatogenesis in stallions
Journal of Animal Science and Technology, 2022 Spermatogenesis and testis development are highly structured physiological processes responsible for post-pubertal fertility in stallions. Spermatogenesis comprises spermatocytogenesis, meiosis, and spermiogenesis.
Muhammad Shakeel, Minjung Yoon
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Transcriptome profiling of developing testes and spermatogenesis in the Mongolian horse
BMC Genetics, 2020 Background Horse testis development and spermatogenesis are complex physiological processes. Methods To study these processes, three immature and three mature testes were collected from the Mongolian horse, and six libraries were established using high ...
Bei Li +8 more
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Three-Dimensional Analysis of Busulfan-Induced Spermatogenesis Disorder in Mice
Frontiers in Cell and Developmental Biology, 2020 We examined if the distribution of impaired or normal spermatogenesis differs along the length of seminiferous tubules in disorders of spermatogenesis. For this purpose, three-dimensional (3D) reconstruction of seminiferous tubules was performed in mice ...
Hiroki Nakata +3 more
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