Results 11 to 20 of about 102,741 (261)

Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis

open access: yesCells, 2022
Spermatogenesis is a prolonged and highly ordered physiological process that produces haploid male germ cells through more than 40 steps and experiences dramatic morphological and cellular transformations.
Yi Xiong, Chao Yu, Qianting Zhang
doaj   +2 more sources

Genes Regulating Spermatogenesis and Sperm Function Associated With Rare Disorders

open access: yesFrontiers in Cell and Developmental Biology, 2021
Spermatogenesis is a cell differentiation process that ensures the production of fertilizing sperm, which ultimately fuse with an egg to form a zygote.
Emma Linn   +4 more
doaj   +2 more sources

Novel Gene Regulation in Normal and Abnormal Spermatogenesis

open access: yesCells, 2021
Spermatogenesis is a complex and dynamic process which is precisely controlledby genetic and epigenetic factors. With the development of new technologies (e.g., single-cell RNA sequencing), increasingly more regulatory genes related to spermatogenesis ...
Li Du   +7 more
doaj   +2 more sources

The Roles of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Spermatogenesis and Folliculogenesis Revisited

open access: yesInternational Journal of Molecular Sciences, 2021
Spermatogenesis and folliculogenesis involve cell–cell interactions and gene expression orchestrated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
O. Oduwole, I. Huhtaniemi, M. Misrahi
semanticscholar   +1 more source

Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder

open access: yesRedox Biology, 2021
Copper (Cu) is a necessary micronutrient at lower concentration, while excessive Cu exposure or Cu homeostasis disorders can lead to toxicity. The mechanism of male reproductive toxicity induced by Cu is still unknown.
Hongrui Guo   +13 more
semanticscholar   +1 more source

Mitochondrial Functionality in Male Fertility: From Spermatogenesis to Fertilization

open access: yesAntioxidants, 2021
Mitochondria are structurally and functionally distinct organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to spermatozoa. They can also produce reactive oxidation species (ROS).
Yoo-Jin Park, M. Pang
semanticscholar   +1 more source

The molecular evolution of spermatogenesis across mammals

open access: yesbioRxiv, 2021
The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological and molecular level in mammals^ 1 – 6 , probably owing to the evolutionary pressure on males to be reproductively successful^ 7 .
Florent Murat   +23 more
semanticscholar   +1 more source

Disrupted spermatogenesis in a metabolic syndrome model: the role of vitamin A metabolism in the gut–testis axis

open access: yesGut, 2021
Objective Effects of the diet-induced gut microbiota dysbiosis reach far beyond the gut. We aim to uncover the direct evidence involving the gut–testis axis in the aetiology of impaired spermatogenesis.
Teng Zhang   +9 more
semanticscholar   +1 more source

In vitro mouse spermatogenesis with an organ culture method in chemically defined medium. [PDF]

open access: yesPLoS ONE, 2018
We previously reported the successful induction and completion of mouse spermatogenesis by culturing neonatal testis tissues. The culture medium consisted of α-minimum essential medium (α-MEM), supplemented with Knockout serum replacement (KSR) or ...
Hiroyuki Sanjo   +13 more
doaj   +1 more source

Single-Cell RNA Sequencing of the Testis of Ciona intestinalis Reveals the Dynamic Transcriptional Profile of Spermatogenesis in Protochordates

open access: yesCells, 2022
Spermatogenesis is a complex and continuous process of germ-cell differentiation. This complex process is regulated by many factors, of which gene regulation in spermatogenic cells plays a decisive role.
Yanan Li   +11 more
doaj   +1 more source

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