Results 51 to 60 of about 38,872 (182)

EP300‐interacting inhibitor of differentiation 3 is required for spermatogenesis in mice

Andrology, EarlyView.
Abstract Background Mammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout.
Ping Zhang, Longsheng Zhang, Li Yu, Xinli Zhou, Xu Chen, Yuchuan Zhou, Ningling Wang, Hui Zhu   +7 more
wiley   +1 more source

Role of intra‐individual variation in the detection of thresholds for DFI and for misclassification rates: A retrospective analysis of 14,775 SCSA® tests

Andrology, EarlyView.
Abstract Background Sperm DNA damage is associated with reduced male fertility after natural conception and intrauterine insemination. However, the impact on in vitro fertilization (IVF) and especially intracytoplasmic sperm injection (ICSI) treatments is still unclear.
Preben Christensen, Robert Fischer, Wolfgang Schulze, Vera Baukloh, Kimberly Kienast, Graham Coull, Erik T. Parner   +6 more
wiley   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Semen cryopreservation and storage in liquid nitrogen: Impact on chromatin compaction

Andrology, EarlyView.
Abstract Background Sperm cryopreservation is a consolidate option for long‐term male fertility preservation. The freezing/thawing procedure causes detrimental effects to spermatozoa, including damage to viability, motility, membrane composition, and DNA, whereas the effect on sperm chromatin compaction is less studied.
Lara Tamburrino, Giulia Traini, Maria Emanuela Ragosta, Sara Dabizzi, Sara Vezzani, Flavia Scarpa, Linda Vignozzi, Elisabetta Baldi, Sara Marchiani   +8 more
wiley   +1 more source

Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice

Andrology, EarlyView.
Abstract Background Inhibition of sperm maturation in the epididymis is a promising post‐testicular strategy for short‐acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice.
Yuki Oyama, Kentaro Shimada, Haruhiko Miyata, Rie Iida‐Norita, Chihiro Emori, Maki Kamoshita, Seiya Oura, Ryohei Katayama, Martin M. Matzuk, Masahito Ikawa   +9 more
wiley   +1 more source

A WHO 2021‐based comprehensive scheme outlining sperm parameters’ associations with IVF outcomes in PGT‐A cycles

Andrology, EarlyView.
Abstract Objective To examine the association between semen parameters, assessed according to World Health Organization (WHO)‐2021 criteria, and paternal body mass index (BMI) and age, with embryological and clinical outcomes in ICSI cycles involving preimplantation genetic testing for aneuploidy (PGT‐A).
Rossella Mazzilli, Danilo Cimadomo, Federica Innocenti, Marilena Taggi, Greta Chiara Cermisoni, Sara Ginesi, Lisa Dovere, Laura Albricci, Maurizio Guido, Maria Rosaria Campitiello, Susanna Ferrero, Antonio Capalbo, Alberto Vaiarelli, Filippo Maria Ubaldi, Alberto Ferlin, Laura Rienzi, Gianluca Gennarelli   +16 more
wiley   +1 more source

Prevalence of HPV infection in the general population of young and adult males in Italy

Andrology, EarlyView.
Abstract Background The most prevalent sexually transmitted disease in the world has the human papillomavirus (HPV) as its etiological agent. Objectives To evaluate the prevalence of previous and actual HPV infection and the clinical manifestations in unselected males.
Giuseppe Grande, Andrea Graziani, Luca De Toni, Federica Finocchi, Adriano Presciutti, Sara Corrò, Alberto Ferlin, Andrea Garolla   +7 more
wiley   +1 more source

Effects of AZFc (b2/b4, b1/b3, b2/b3, and gr/gr) deletions and primary duplications on the outcomes of the first intracytoplasmic sperm injection treatment cycle: A single‐center retrospective cohort study

Andrology, EarlyView.
Abstract Background Current advances in high‐throughput sequencing technology enable the precise identification of Y chromosome microdeletion and primary duplication in infertile couples, but the mechanism and clinical significance of these mutations in assisted reproductive techniques remain unclear.
Linlin Li, Xiangyin Liu, Xinying Wang, Hongguo Zhang, Ruizhi Liu   +4 more
wiley   +1 more source

Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptive

Andrology, EarlyView.
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin, Kyuri Kim, Toufan Parman, Janet Gahagen, Mary B. Zelinski, Tiffany Adevai, Christina Wang, Liang Tang, Lalitha Iyer, Aaron Endsley, Diana L. Blithe, Min S. Lee   +11 more
wiley   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source