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Spermidine in health and disease
Science, 2018 Having your longevity and eating too Although caloric restriction has clear benefits for maximizing health span and life span, it is sufficiently unpleasant that few humans stick to it. Madeo et al. review evidence that increased intake of the polyamine spermidine appears to reproduce many of the healthful
Frank Madeo +3 more
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Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders
Neuropeptides, 2020 Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis.
Runali Sankhe +2 more
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Nutrients, 2023 (1) Background: Spermidine is a biogenic polyamine that plays a crucial role in mammalian metabolism. As spermidine levels decline with age, spermidine supplementation is suggested to prevent or delay age-related diseases.
Stefan Senekowitsch +2 more
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Nutritional Aspects of Spermidine
Annual Review of Nutrition, 2020Natural polyamines (spermidine and spermine) are small, positively charged molecules that are ubiquitously found within organisms and cells. They exert numerous (intra)cellular functions and have been implicated to protect against several age-related diseases. Although polyamine levels decline in a complex age-dependent, tissue-, and cell type–specific
Frank, Madeo +6 more
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Helicobacter pylori does not use spermidine synthase to produce spermidine
Biochemical and Biophysical Research Communications, 2017Helicobacter pylori is the primary pathogen associated to gastritis and gastric cancer. Growth of H. pylori depends on the availability of spermidine in vivo. Interestingly, the genome of H. pylori contains an incomplete set of genes for the classical pathway of spermidine biosynthesis.
Huawei Zhang, Shannon Wing Ngor Au
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Acetylation of spermidine in polyamine catabolism
Biochimica et Biophysica Acta (BBA) - General Subjects, 1980Treatment with thioacetamide (150 mg/kg) was used to enhance polyamine metabolism in rat liver. The increased uptake and catabolism of [14C]spermine and the changes of putrescine, spermidine and spermine concentrations indicated enhanced polyamine turnover rates.
N, Seiler, F N, Bolkenius, B, Knödgen
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Stabilization of 70S Ribosomes by Spermidine
Nature New Biology, 1971RIBOSOMAL subunits in Escherichia coli dissociate and reasso-ciate after each round of translation1, but it is not known whether separation occurs at termination of protein synthesis2, or whether they are released as “free” 70S ribosomes and subsequently dissociate3.
S J, Hardy, G, Turnock
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