Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis [PDF]
Advanced ScienceSpermiogenesis is the committed step of sperm production, during which spermatid cells undergo dramatic morphological transformations and transcriptional silencing.
Tianyu Zhu +25 more
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Description of the Seminiferous Epithelium Cycle Stages in the Zebra Finch Taeniopygia guttata [PDF]
AnimalsSpermatogenesis in passerine birds remains poorly characterized. Previous studies focused on the steps of spermiogenesis, while a detailed staging of the seminiferous epithelium cycle is still lacking for this order.
Tatiana Bikchurina +5 more
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ELAPOR1 mediated vesicle traffic is required for acrosome biogenesis and male fertility in mice [PDF]
Cellular and Molecular Life SciencesSpermiogenesis is the post-meiotic differentiation and morphological change of the haploid spermatids. Acrosome biogenesis is one of the key events of spermiogenesis, which generates a specialized membranous organelle crucial for shaping the balanced ...
Runze Ding +7 more
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HIPK4 is essential for murine spermiogenesis
eLife, 2020 Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here that ...
J Aaron Crapster +12 more
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Loss of C-Terminal Coiled-Coil Domains in SDCCAG8 Impairs Centriolar Satellites and Causes Defective Sperm Flagellum Biogenesis and Male Fertility [PDF]
CellsSperm flagellum defects are tightly associated with male infertility. Centriolar satellites are small multiprotein complexes that recruit satellite proteins to the centrosome and play an essential role in sperm flagellum biogenesis, but the precise ...
Kecheng Li +6 more
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Chromatin dynamics during spermiogenesis
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2014 The function of sperm is to safely transport the haploid paternal genome to the egg containing the maternal genome. The subsequent fertilization leads to transmission of a new unique diploid genome to the next generation. Before the sperm can set out on its adventurous journey, remarkable arrangements need to be made during the post-meiotic stages of ...
Rathke, C +3 more
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Tex13a Optimizes Sperm Motility via Its Potential Roles in mRNA Turnover
Frontiers in Cell and Developmental Biology, 2021 mRNAs have been found to undergo substantial selective degradation during the late stages of spermiogenesis. However, the mechanisms regulating this biological process are unknown. In this report, we have identified Tex13a, a spermatid-specific gene that
Yinchuan Li +10 more
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Journal of Lipid Research, 2010 Delta-6 desaturase-null mice (−/−) are unable to synthesize highly unsaturated fatty acids (HUFAs): arachidonic acid (AA), docosahexaenoic acid (DHA), and n6-docosapentaenoic acid (DPAn6).
Manuel Roqueta-Rivera +9 more
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Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice
Reproductive Medicine and Biology, 2022 Purpose Spermiogenesis, the process of deformation of sperm head morphology and flagella formation, is a phenomenon unique to sperm. Axonemal dynein light chain proteins are localized to sperm flagella and are known to be involved in sperm motility. Here,
Yuki Hiradate +10 more
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Inactivation of the Celf1 gene that encodes an RNA-binding protein delays the first wave of spermatogenesis in mice. [PDF]
PLoS ONE, 2012 BACKGROUND: The first wave of spermatogenesis in mammals is characterized by a sequential and synchronous appearance of germ cells in the prepubertal testis.
Marie Cibois +4 more
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