Results 141 to 150 of about 1,019 (188)

Just the facts: diagnosis and management of generalized pustular psoriasis. [PDF]

CJEM
Yeung J, Prajapati VH, Mutter E, Gooderham M.   +3 more
europepmc   +1 more source

Real‐World Safety Profile of Spesolimab in Generalized Pustular Psoriasis: Insights From Japan as Part of a Multinational Expanded Access Program (EAP)

The Journal of Dermatology, Volume 53, Issue 2, Page 351-356, February 2026.
Generalized pustular psoriasis (GPP) is a heterogeneous, systemic neutrophilic inflammatory disease, characterized by chronic symptoms and recurrent flares, which can be potentially life‐threatening. Spesolimab, an interleukin‐36 receptor antagonist, has
A. Morita, Yayoi Tada, Y. Tsunemi, Mayumi Komine, T. Kanekura, Shinichi Imafuku, Toshiya Takahashi, Xuemei Ding, Nichiren Pillai, Morihisa Saitoh, Rafael Sani Simoes, Nora Pöntynen, Keiichi Yamanaka   +12 more
semanticscholar   +2 more sources

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Spesolimab for the Treatment of Generalized Pustular Psoriasis Flares

Journal of Drugs in Dermatology
Generalized pustular psoriasis (GPP) is a rare, life-threatening neutrophilic skin condition characterized by widespread sterile eruptions. Treatment approaches vary due to a lack of standardized guidelines. Interleukin-36 signaling is involved in GPP activation and disease progression.
Abukhadra, Sabine L., Parraga, Shirley P., Feldman, Steven R.   +2 more
openaire   +4 more sources

Spesolimab: A Review of the First IL-36 Blocker Approved for Generalized Pustular Psoriasis

Annals of Pharmacotherapy
Objective: This article reviews clinical trial data that assesses the safety, efficacy, and clinical application of spesolimab, an interleukin-36 (IL-36) blocker, for the treatment of generalized pustular psoriasis (GPP). Data sources: A review of the literature was conducted using the search terms: “spesolimab,” “BI 655130,” and “spevigo” in MEDLINE ...
Gaurav N. Pathak, Emily Wang, Jimmy Dhillon, Prachi N. Parikh, Reem Esseghir, Babar K. Rao, Steven R. Feldman   +6 more
openaire   +4 more sources

Spesolimab Response in a Girl With Acrodermatitis Continua of Hallopeau

JAMA Dermatology
This case report summarizes the treatment of acrodermatitis continua of Hallopeau with spesolimab in a 9-year-old girl.
Youcong, Wang, Li, Zhang, Jie, Zheng, Xia, Li, Lihong, Chen   +4 more
openaire   +3 more sources

Spesolimab: A Novel Treatment for Pustular Psoriasis

Journal of Cutaneous Medicine and Surgery, 2020
No abstract available Keywords: IL-36; acrodermatitis continua of hallopeau; generalized pustular psoriasis; localized pustular psoriasis; pustular psoriasis; spesolimab.
Kayadri Ratnarajah, Abdulhadi Jfri, Ivan V. Litvinov, Elena Netchiporouk   +3 more
openaire   +2 more sources

A rare severe acrodermatitis continua of Hallopeau treated with spesolimab

The Journal of Dermatology
Chenggong Guan, Zhongyi Xu, Yan Wang, Lijuan Zhou, Chengfeng Zhang, Zhenghua Zhang   +5 more
openaire   +3 more sources