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Automated evaluation of tumor spheroid behavior in 3D culture using deep learning-based recognition.

Biomaterials, 2021
Three-dimensional in vitro tumor models provide more physiologically relevant responses to drugs than 2D models, but the lack of proper evaluation indices and the laborious quantitation of tumor behavior in 3D have limited the use of 3D tumor models in ...
Zaozao Chen   +15 more
semanticscholar   +1 more source

Towards spheroid-omics

Nature Methods, 2021
The MISpheroID knowledgebase records and organizes experimental parameters from thousands of cancer spheroid experiments, revealing heterogeneity and a lack of transparency in key spheroid research reporting practices.
openaire   +2 more sources

Injectable MSC Spheroid and Microgel Granular Composites for Engineering Tissue

Advances in Materials
Many cell types require direct cell–cell interactions for differentiation and function; yet, this can be challenging to incorporate into 3‐dimensional (3D) structures for the engineering of tissues.
Nikolas Di Caprio   +3 more
semanticscholar   +1 more source

A review of manufacturing capabilities of cell spheroid generation technologies and future development

Biotechnology and Bioengineering, 2020
Spheroid culture provides cells with a three‐dimensional environment that can better mimic physiological conditions compared to monolayer culture. Technologies involved in the generation of cell spheroids are continuously being innovated to produce ...
Dan Liu, Sixun Chen, M. Naing
semanticscholar   +1 more source

Axonal spheroids in neurodegeneration

Molecular and Cellular Neuroscience, 2021
Axonal spheroids are bubble-like biological features that form on most degenerating axons, yet little is known about their influence on degenerative processes. Their formation and growth has been observed in response to various degenerative triggers such as injury, oxidative stress, inflammatory factors, and neurotoxic molecules.
Yu, Yong   +3 more
openaire   +2 more sources

Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis.

Lab on a Chip, 2019
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly progressing from academic proof-of-concept studies to valid solutions to real-world problems.
Jihoon Ko   +6 more
semanticscholar   +1 more source

Anticancer drug discovery using multicellular tumor spheroid models

Expert Opinion on Drug Discovery, 2019
Introduction: Despite the increasing financial outlay on cancer research and drug discovery, many advanced cancers remain incurable. One possible strategy for increasing the approval rate of new anticancer drugs for use in clinical practice could be ...
M. Zanoni   +4 more
semanticscholar   +1 more source

Bistable spheroidal optical solitons

Physical Review A, 1992
The possible forms the intensity dependence of the nonlinear refractive index would have to take for bistable light bullets to exist are examined. Bistable light bullets are propagating spheroidal optical solitons characterized by different sizes and intensity profiles but with the same energy.
, Enns, , Rangnekar
openaire   +2 more sources

Rhabdostyla spheroides

Rhabdostyla spheroides (Fromentel 1874) — Fig. 4, M’ Epistylis spheroides Fromentel, 1874: 240, pl. IV, fig. 4 Rhabdostyla sphaeroides Kent, 1881 –1882: 666, pl. XXXIII, fig. 10 [Rhabdostyla] (Rhabdostyla) sphaeroides Kahl, 1935: 678, pl. 129, fig. 16 Diagnosis: Size about 60µm.
Souza, Pedro Mendes De   +2 more
openaire   +1 more source

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