Results 51 to 60 of about 2,192 (300)

Study on Spheroidization of Tungsten Powders by RF Plasma Processing

, 2011
Spherical tungsten powders were synthesized by (RF) argon plasma with irregular tungsten powders in this paper. The microstructure and crystallographic phases of the synthesized powders were characterized using scanning electron microscopy (SEM) and X ...
Jun Jie Hao, Zhi Meng Guo, Yan Wei Sheng
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Identification of Cementite Newgrowths Near Triple Boundary Grain Intersection in Spheroidized Heat-resisting Pearlitic Steel

Известия высших учебных заведений: Проблемы энергетики, 2017
The microstructure of pearlitic steel 12Х1МФ spent its servis life has been investigated by the microscope Neofot - 32. To identify the cementite grain and carry out its elemental analysis was used the multipurpose scanning electron microscope ЕVO - 50 c
V. V. Gerasimov
doaj   +1 more source

Influence of the Initial Microstructure on the Spheroidization of SAE 52100 Bearing Steel

, 2018
High carbon Cr-bearing SAE 52100 is widely used for bearing production. The in-service microstructure of bearing steel is tempered high C martensite, which has superior mechanical properties in severe rolling fatigue conditions. The bearings are produced
Hwang, H, De Cooman, BC
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Influence of Microstructure and Texture on Tensile Properties of an As-Rolled Ti₂AlNb-Based Alloy

Metals
Ti2AlNb-based alloys are widely used in aerospace applications due to their excellent high-temperature mechanical properties. This study aims to investigate the texture, microstructural evolution, and phase transformation behavior of Ti2AlNb-based alloy ...
Caihong Jing, Shoujiang Qu, Aihan Feng, Hao Wang, Daolun Chen   +4 more
doaj   +1 more source

Aço ABNT 1045 esferoidizado: estudo da cinética de coalescimento e correlações entre microestruturas e propriedades mecânicas [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência e Engenharia de MateriaisEste trabalho teve por objetivo estudar o processo de recozimento de esferoidização de um aço SAE 1045 e ...
Rocha, Marcio Roberto da
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source