Results 51 to 60 of about 4,209 (305)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The stability of Pt nanofilaments in a Au-matrix composite [PDF]

, 2007
Au-7 at.% Pt Deformation-processed Metal Metal Composite (DMMC) was isothermally annealed at various times and temperatures. Avrami and Arrhenius relations were used to evaluate the kinetics of the transformation from the initial metastable ...
Russell, Alan, Russell, Alan, Wongpreedee, Kageeporn   +2 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Apparatus for production of ultrapure amorphous metals utilizing acoustic cooling [PDF]

, 1985
Amorphous metals are produced by forming a molten unit of metal and deploying the unit into a bidirectional acoustical levitating field or by dropping the unit through a spheroidizing zone, a slow quenching zone, and a fast quenching zone in which the ...
Lee, M. C.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Thin Wall Ductile Iron Castings: Technological Aspects [PDF]

, 2013
The paper discusses the reasons for the current trend of substituting ductile iron castings by aluminum alloys castings.However, it has been shown that ductile iron is superior to aluminum alloys in many applications.
E Fraś, M. Górny, W. Kapturkiewicz
core   +4 more sources

Influence of Microstructure and Texture on Tensile Properties of an As-Rolled Ti₂AlNb-Based Alloy

Metals
Ti2AlNb-based alloys are widely used in aerospace applications due to their excellent high-temperature mechanical properties. This study aims to investigate the texture, microstructural evolution, and phase transformation behavior of Ti2AlNb-based alloy ...
Caihong Jing, Shoujiang Qu, Aihan Feng, Hao Wang, Daolun Chen   +4 more
doaj   +1 more source

Design of a Uranium Dioxide Spheroidization System [PDF]

, 2013
The plasma spheroidization system (PSS) is the first process in the development of tungsten-uranium dioxide (W-UO2) fuel cermets. The PSS process improves particle spherocity and surface morphology for coating by chemical vapor deposition (CVD) process ...
Cavender, Daniel P., Frendi, Abdelkader, Mireles, Omar R.   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Effect of cyclic heat treatment with hot deformation on the microstructure and structural orientation of TC17 titanium alloy lamellae

工程科学学报, 2017
The effects of cyclic heat treatment and hot deformation on the spheroidization and orientation of the TC17 titanium alloy were investigated using a light microscope (LM) and electron backscattered diffraction (EBSD).
CHEN Shao-hua, ZHANG Mai-cang, JIA Meng-liu, PENG Tao   +3 more
doaj   +1 more source