Results 71 to 80 of about 2,206 (301)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Effect of cyclic heat treatment with hot deformation on the microstructure and structural orientation of TC17 titanium alloy lamellae

open access: yes工程科学学报, 2017
The effects of cyclic heat treatment and hot deformation on the spheroidization and orientation of the TC17 titanium alloy were investigated using a light microscope (LM) and electron backscattered diffraction (EBSD).
CHEN Shao-hua   +3 more
doaj   +1 more source

Fabrication of spherical Ti–6Al–4V powder for additive manufacturing by radio frequency plasma spheroidization and deoxidation using calcium

open access: yesJournal of Materials Research and Technology, 2020
Commercial hydride-dehydride Ti–6Al–4V powder was used as raw material to fabricate high-quality spherical Ti–6Al–4V powder by radio frequency (RF) plasma spheroidization and calcium deoxidation in this work.
Jing Li   +3 more
doaj   +1 more source

Dwarf Spheroidal Galaxies [PDF]

open access: yesSymposium - International Astronomical Union, 1994
Dwarf Spheroidal (dSph) galaxies are the faintest baryonic systems recognized as galaxies. Understanding the structure and stellar populations of these systems is critical for the modelling of their formation and evolution, and by extension, for understanding the general problem of galaxy formation ...
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Effect of Friction Temperature on Spheroidization and Refinement of Si Particles in Hypereutectic Al-Si Alloys [PDF]

open access: yes, 2010
The effect of the temperature at the friction surface on spheroidization and refinement of Si particles in hypereutectic Al-30Si alloys was investigated.
Ming Zhou   +4 more
core   +1 more source

Analysis on the Leakage of Boiler Heating Surface Tube of Thermal Power Plant

open access: yes发电技术, 2018
The high-temperature superheater bursting accident is one of the main factors that affect the safe operation of power plants, and causes the greatest loss.
Bo XU, Hai ZHAO, Qiang GAO
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

Influence of the Initial Microstructure on the Spheroidization of SAE52100 Bearing Steel [PDF]

open access: yes, 2015
MasterThe high carbon chromium bearing steel SAE 52100 is widely used in the automotive industry and in the motor and machinery construction industries. The in-service microstructure of bearing steel is tempered high C martensite.
황훈
core  

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