Results 71 to 80 of about 79,551 (308)
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
The role of copper in disulfiram-induced toxicity and radiosensitisation of cancer cells. [PDF]
, 2013 Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity ...
Babich, John W +5 more
core +1 more source
Drug screening on 3D tumor spheroids
, 2016 We report a versatile platform for the production of spheroids of various dimensions, based on tumor cells only (mono-culture spheroids) or a combination of tumor cells and fibroblasts (co-culture spheroids). Spheroids prepared in microwells of different
Le Gac, Séverine
core +1 more source
3D spheroids enhance NFAT3 and CXCR4 expression.
, 2014 PCR array of transcription factors was performed according to manufacturer's protocol. The 3D spheroids have 100,000 cells per spheroid. (A) A list of transcriptional factors with the corresponding fold change in mRNA expression in cultured 3D spheroids ...
Keven Huang (675616) +2 more
core +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Formation and Migration of Breast Cancer Spheroids [PDF]
Invasive breast cancer affects 1 in 8 women during their lifetime. Current cancer research uses 2-D cell culturing, which does not accurately represent tumor behavior.
Hurley, Casey M.
core +4 more sources
Cold storage of porcine hepatocyte spheroids for spheroid bioartificial liver [PDF]
Xenotransplantation, 2019 AbstractBackground and aimsCell‐based therapies for liver disease such as bioartificial liver rely on a large quantity and high quality of hepatocytes. Cold storage was previously shown to be a better way to preserve the viability and functionality of hepatocytes during transportation rather than freezing, but this was only proved at a lower density of
Yi Li +6 more
openaire +2 more sources
Positronium in melanoma spheroids
, 2022 It was recently demonstrated that newly invented positronium imaging may be used for improving cancer diagnostics by providing additional information about tissue pathology with respect to the standardized uptake value currently available in positron ...
Karimi, Hanieh +5 more
core +1 more source
Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling
FEBS Open Bio, EarlyView.Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt +2 more
wiley +1 more source