Results 51 to 60 of about 79,551 (308)

Cell compositions of spheroids.

, 2019
Cell compositions of spheroids.
Yosuke Takeoka (6440231), Abdelmotagaly Elgalad (6440255), Tomoyuki Tetsuo (6440246), Naoto Matsuo (6400973), Daisuke Taniguchi (6440234), Shigekazu Hidaka (3387698), Shosaburo Oyama (6440243), Ryusuke Machino (6440237), Katsunori Takagi (6440252), Koichi Nakayama (790706), Tomoshi Tsuchiya (3438134), Yasuaki Taura (6440249), Naoya Yamasaki (846245), Keitaro Matsumoto (3438137), Takashi Nonaka (76323), Takeshi Nagayasu (846246), Masaaki Moriyama (6440240), Masaki Kunizaki (6440258), Shuichi Tobinaga (6195464), Takuya Yoshida (482417)   +19 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

3D hanging spheroid plate for high-throughput CAR T cell cytotoxicity assay

Journal of Nanobiotechnology, 2022
Background Most high-throughput screening (HTS) systems studying the cytotoxic effect of chimeric antigen receptor (CAR) T cells on tumor cells rely on two-dimensional cell culture that does not recapitulate the tumor microenvironment (TME).
Zhenzhong Chen, Seokgyu Han, Arleen Sanny, Dorothy Leung-Kwan Chan, Danny van Noort, Wanyoung Lim, Andy Hee-Meng Tan, Sungsu Park   +7 more
doaj   +1 more source

Shape factor extremes for prolate spheroids [PDF]

, 1976
summary:Microscopic prolate spheroids in a given volume of an opaque material are considered. The extremes of the shape factor of the spheroids are studied.
Hlubinka, Daniel, Luis-M. Cruz Orive
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Pre‐Vascularized hMSC and hPDC Spheroids as Building Block Units for Bone Tissue Engineering

Advanced Materials Interfaces
Spheroids have emerged as valuable tools in bone tissue engineering, mimicking the cellular interactions in native tissues. However, the application of small and low‐cell‐number spheroids for simultaneous bone regeneration and vascularization remains ...
Filipa C. Teixeira, Virginie Joris, Martijn van Griensven, Lorenzo Moroni, Carlos Mota   +4 more
doaj   +1 more source

Enhancing Bone Formation Through bFGF-Loaded Mesenchymal Stromal Cell Spheroids During Fracture Healing in Mice

Bioengineering
This study aimed to evaluate the osteogenic potential of mesenchymal stromal cell (MSC) spheroids combined with the basic fibroblast growth factor (bFGF) in a mouse femur fracture model.
Kugo Takeda, Hiroki Saito, Shintaro Shoji, Hiroyuki Sekiguchi, Mitsuyoshi Matsumoto, Masanobu Ujihira, Masayuki Miyagi, Gen Inoue, Masashi Takaso, Kentaro Uchida   +9 more
doaj   +1 more source

The spheroidizing tendency and spheroidization mechanism of 75Cr1 steel [PDF]

MATEC Web of Conferences, 2018
Spheroidization annealing process was carried out on 75Cr1 steel after cold rolling. Using TEM, SEM and image analysis software Image-Pro Plus 6.0, the effects of cold rolling and spheroidization processes on microstructure and mechanical properties were analyzed.
Huo Jiping, Zhou Chong, Wang Hua
openaire   +2 more sources

Spheroid Engineering in Microfluidic Devices

ACS Omega, 2023
Two-dimensional (2D) cell culture techniques are commonly employed to investigate biophysical and biochemical cellular responses. However, these culture methods, having monolayer cells, lack cell-cell and cell-extracellular matrix interactions, mimicking the cell microenvironment and multicellular organization.
Atakan Tevlek, Seren Kecili, Ozge S. Ozcelik, Haluk Kulah, H. Cumhur Tekin   +4 more
openaire   +4 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source