Results 121 to 130 of about 48,095 (292)

Self-Protection against the Sphingolipid Biosynthesis Inhibitor Fumonisin B ₁ Is Conferred by a FUM Cluster-Encoded Ceramide Synthase

, 2020
Slavica Janevska, Iuliia Ferling, Katarina Jojić, Julia Rautschek, Sandra Hoefgen, Robert H. Proctor, Falk Hillmann, Vito Valiante   +7 more
openalex   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Synthesis of Sphingolipids

, 1980
Hirohumi HIRATA
openalex   +2 more sources

Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines

, 2020
Sylvestre P. J. T. Bachollet, Vito Vece, Alison N. McCracken, Brendan T. Finicle, Elizabeth Selwan, Nadine Ben Romdhane, Amogha Dahal, Cuauhtemoc Ramirez, Aimee L. Edinger, Stephen Hanessian   +9 more
openalex   +2 more sources

Activation of 3-Phosphoinositide-dependent Kinase 1 (PDK1) and Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) by Short-chain Sphingolipid C4-ceramide Rescues the Trafficking Defect of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (ΔF508-CFTR) [PDF]

, 2014
H. Caohuy, Qingfeng Yang, Yvonne Eudy, Thien-An Ha, Andrew E. Xu, Matthew L. Glover, Raymond A. Frizzell, Catherine Jozwik, Harvey B. Pollard   +8 more
openalex   +1 more source

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, EarlyView.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Opaganib Promotes Weight Loss and Suppresses High-Fat Diet-Induced Obesity and Glucose Intolerance

Diabetes, Metabolic Syndrome and Obesity
Lynn W Maines, Staci N Keller, Ryan A Smith, Charles D Smith Apogee Biotechnology Corporation, Hummelstown, PA, USACorrespondence: Charles D Smith, Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, PA, 17036, USA, Email ...
Maines LW, Keller SN, Smith RA, Smith CD
doaj  

Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle viaK_Ca1.1 upregulation [PDF]

, 2015
Shinkyu Choi, Ji Aee Kim, Tae Hun Kim, Haiyan Li, Kyong‐Oh Shin, Young Moo Lee, Seikwan Oh, Yael Pewzner‐Jung, Anthony H. Futerman, Suk Hyo Suh   +9 more
openalex   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

Speculation of Sphingolipids in Capsanthin by Ultra-Performance Liquid Chromatography Coupled with Electrospray Ionization-Quadrupole—Time-of-Flight Mass Spectrometry [PDF]

, 2023
Meili Xu, Lijun Qi, Xingfu Cai, Tong Cao, Rumeng Tang, Kaihang Cao, Yunhe Lian   +6 more
openalex   +1 more source