Results 271 to 280 of about 68,956 (338)

Variations in skin biophysical parameters with age, sex and breed in dogs

Veterinary Dermatology, EarlyView.
Background – Understanding the physiological and biophysical characteristics of skin provides information for developing appropriate management strategies for skin diseases. However, in dogs, variations in skin biophysical parameters, such as age, sex and breed, remain poorly understood.
Je‐Seong Kwon, Eun‐Yeong Bok, Daekyoung Kim, Chae‐Yeon Hong, Yong‐ho Choe, Jaemin Kim, Tae Sung Hwang, Sung‐Lim Lee, Ji‐Seon Yoon   +8 more
wiley   +1 more source

Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1-phosphate receptor 1. [PDF]

Fluids Barriers CNS
Nosratabadi F, Endres LM, Schumacher F, Claus H, Kleuser B, Kim BJ, Schubert-Unkmeir A.   +6 more
europepmc   +1 more source

Activation of TRPA1 and TRPM3 triggers Ca2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal horn

The Journal of Physiology, EarlyView.
Abstract figure legend Transient receptor potential ankyrin 1 (TRPA1) and melastatin 3 (TRPM3) activation regulate pre‐ and postsynaptic Ca2+ concentrations and synaptic activity in the dorsal horn of the spinal cord. Left: a model that describes how activation of TRPA1 and TRPM3 channels induces an influx of Ca2+ in the central terminals of sensory ...
Yaroslav E. Andrianov, Alex L. Keyes, Charles A. Warwick, Miriam C. McDonough, Leonid P. Shutov, Kavita S. Solanki, Jon M. Resch, Alexander G. Bassuk, Nana Voitenko, Pavel Belan, Yuriy M. Usachev   +10 more
wiley   +1 more source

Ceramide kinase suppresses ferroptosis and protects against alcohol-associated liver disease through the p38 MAPK-HSPB1 pathway. [PDF]

Hepatol Commun
Tao Y, Wang H, Peng Y, Chen Y, Liu X, Qi G, Wang H, Bai L, Qian Y.   +8 more
europepmc   +1 more source

Spatial transcriptomics iterative hierarchical clustering (stIHC): A novel method for identifying spatial gene co‐expression modules

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Recent advancements in spatial transcriptomics (ST) technologies allow researchers to simultaneously measure RNA expression levels for hundreds to thousands of genes while preserving spatial information within tissues, providing critical insights into spatial gene expression patterns, tissue organization, and gene functionality.
Catherine Higgins, Jingyi Jessica Li, Michelle Carey   +2 more
wiley   +1 more source

Apolipoprotein M expression modifies the sphingolipid landscape in murine blood and lymph. [PDF]

Front Immunol
Blaho VA, Minyard JT.
europepmc   +1 more source

Syringomycin E Inhibition of Saccharomyces cerevisiae : Requirement for Biosynthesis of Sphingolipids with Very-Long-Chain Fatty Acids and Mannose- and Phosphoinositol-Containing Head Groups

, 2000
Stephen D. Stock, Hiroko Hama, Jeffrey A Radding, Debra A. Young, Jon Y. Takemoto   +4 more
openalex   +2 more sources

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

Self-Assembly of Accumulated Sphingolipids into Cytotoxic Fibrils in Globoid Cell Leukodystrophy and Their Inhibition by Small Molecules In Vitro. [PDF]

ACS Nano
Kumar S, Nikelshparg E, Pilátová J, Paul A, Kumar V, Koren G, Beck R, Jensen HH, Segal D.   +8 more
europepmc   +1 more source

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

, 2000
Arnd Pralle, Patrick Keller, Ernst‐Ludwig Florin, Kai Simons, J. K. H. Hörber   +4 more
openalex   +1 more source