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Sphingolipids and Response to Chemotherapy
2013Chemotherapy is frequently used to treat primary or metastatic cancers, but intrinsic or acquired drug resistance limits its efficiency. Sphingolipids are important regulators of various cellular processes including proliferation, apoptosis, differentiation, angiogenesis, stress, and inflammatory responses which are linked to various aspects of cancer,
Marie-Thérèse Dimanche-Boitrel +2 more
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Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
Science, 1989The discovery that breakdown products of cellular sphingolipids are biologically active has generated interest in the role of these molecules in cell physiology and pathology. Sphingolipid breakdown products, sphingosine and lysosphingolipids, inhibit protein kinase C, a pivotal enzyme in cell regulation and signal transduction.
Robert M. Bell, Yusuf A. Hannun
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2016
Sphingolipids are ubiquitous components of eukaryotic cell membranes and have been widely studied over the past couple of decades due to the discovery of their involvement in a wide range of biological processes. This chapter focuses on the structure, biosynthesis and degradation of sphingolipids, with particular emphasis on recent studies documenting ...
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Sphingolipids are ubiquitous components of eukaryotic cell membranes and have been widely studied over the past couple of decades due to the discovery of their involvement in a wide range of biological processes. This chapter focuses on the structure, biosynthesis and degradation of sphingolipids, with particular emphasis on recent studies documenting ...
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Sphingolipids in inflammatory hypoxia
Biological Chemistry, 2018Abstract Hypoxia due to rapid tumor growth with impaired neovascularization and inflammation resulting from immune cell activation are hallmarks of cancer. Hypoxia-inducible factors control transcriptional adaptation in response to low oxygen conditions, both in tumor and immune cells.
Glaser, Ulrike G, Fandrey, Joachim
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A view on sphingolipids and disease
Chemistry and Physics of Lipids, 2011Sphingolipid and glycosphingolipid levels and expression of sphingolipid metabolizing enzymes are altered in a variety of diseases or in response to drug treatment. Inherited defects of enzymes and other proteins required for the lysosomal degradation of these lipids lead to human sphingolipidoses.
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Sphingolipids in viral infection
Biological Chemistry, 2015Abstract Viruses exploit membranes and their components such as sphingolipids in all steps of their life cycle including attachment and membrane fusion, intracellular transport, replication, protein sorting and budding. Examples for sphingolipid-dependent virus entry are found for: human immunodeficiency virus (HIV), which besides its protein receptors
Sibylle Schneider-Schaulies +1 more
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Mitochondria as sensors of sphingolipids
Biochimie, 2002Much of the action in the mammalian apoptotic program takes place at the mitochondrial level. Physicochemical characteristics and integrity of mitochondrial membranes may play a crucial role in the recruitment and multimerization of pro-apoptotic Bcl-2 family members, opening of the permeability transition pore complex (PTPC) and the release of ...
TOMASSINI, BARBARA, TESTI, ROBERTO
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2015
: Sphingolipids are found in membranes of both plant and animal cells. Sphingosine, which can be formed from palmitoyl-CoA and serine, is used by cells to form ceramides. Ceramides are the basic structural units of all sphingolipids, and are formed through the union of a very long-chain fatty acids with sphingosine.
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: Sphingolipids are found in membranes of both plant and animal cells. Sphingosine, which can be formed from palmitoyl-CoA and serine, is used by cells to form ceramides. Ceramides are the basic structural units of all sphingolipids, and are formed through the union of a very long-chain fatty acids with sphingosine.
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2008
Publisher Summary Sphingolipids are found in all animals, plants, and fungi, and in some prokaryotic organisms and viruses. They are composed of an sphingoid base backbone to which a fatty acid may be attached through an amide bond and a head group at the primary hydroxyl.
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Publisher Summary Sphingolipids are found in all animals, plants, and fungi, and in some prokaryotic organisms and viruses. They are composed of an sphingoid base backbone to which a fatty acid may be attached through an amide bond and a head group at the primary hydroxyl.
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Introduction: Enigmas of Sphingolipids
2019Sphingolipid biology has enjoyed a remarkable rise to fame over the last two decades. Various molecules from this lipid family have been implicated in a variety of cellular functions in health and disease. Ceramides, which constitute the hub of sphingolipid metabolism, are apoptogenic molecules that have many proposed mechanisms of actions.
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