Results 121 to 130 of about 1,668,301 (239)

Sphingosine‐1‐Phosphate Attenuates LPS‐Induced Inflammatory Cardiac Injury in Association With RASGRP1–S100A9–NLRP3 Signaling

Drug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Lipopolysaccharide (LPS) induces endotoxemia‐associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine‐1‐phosphate (S1P) regulates cardiovascular and immune responses, predominantly through S1P receptors, but whether it also modulates macrophage‐associated inflammatory signaling during LPS ...
Chaofu Yue, Qiaolin Li, Chunyan Li, Taoxian Yang, Xian Huang, Feng Yue, Qiuyu Long, Rong Li, Rong Lei, Qingsong Ma, Caimei Hu, Qian Yang, Yongjun Yan, Yuan Liu, QinYong Yan, Mei Yang   +15 more
wiley   +1 more source

Sorting and membrane organization of GPI-anchored proteins in polarized epithelial cells [PDF]

, 2008
Tivodar, Simona Sanda
core   +1 more source

Fumonisin-Induced Disruptions in Sphingolipid Metabolism: Implications for Steroid Hormone Biosynthesis and Hormone Modulation. [PDF]

Toxins (Basel)
Agyarko E, Ali O, Ikanya L, Zsarnovszky A, Kovács M, Szabó A.   +5 more
europepmc   +1 more source

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Marianna Maddaluno, Laura Cinque, Viviana Cetrangolo, Chiara De Leonibus   +3 more
wiley   +1 more source

Proteome Responses to Acute Inhibition of De Novo Sphingolipid Synthesis Suggest Cancer Combination Therapies. [PDF]

Cancers (Basel)
Luu TTT, Zhang D, Bheemanapally K, Zaman M, Wu Z, Liu Y, Wu X, Kim HE, Zheng L, Ogretmen B, Peng J, Du G.   +11 more
europepmc   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, Volume 41, Issue 11, Page 1188-1200, November 2026.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

<i>APOE</i> Genotypes Modulate the Relationship of Hypertension With Alzheimer's Disease: Associations and Clues of Peripheral Mechanisms. [PDF]

Biol Psychiatry Glob Open Sci
Wu HY, Hou JH, Huang LY, Tan L, Xu W.
europepmc   +1 more source

Serum Lipidomics Profiling Identify Novel Biomarkers of Distal Symmetrical Polyneuropathy in Type 1 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10670-10682, November 2026.
ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk, Tina Okdahl, Marietta Kokla, Tommi Suvitaival, Gurjeet Kaur, Ismo M. Mattila, Simon M. Kienle, Christian Buhl, Knud Yderstræde, Troels S. Jensen, Peter Rossing, Flemming Pociot, Birgitte Brock, Cristina Legido‐Quigley, Páll Karlsson, Christian S. Hansen, Christina Brock, Joachim Størling, Karolina Sulek   +18 more
wiley   +1 more source

Efficacy of Toxfin in Mitigating Mycotoxin Effects in Laying Hens. [PDF]

Animals (Basel)
Lima AV, Pinto JAF, Nascimento CHD, Rodrigues AB, Souza PEL, Brito Filho HA, Silva RDS, Correa LM, Guerra RR, Silva EGD, Ribeiro AG, Arrais JCRR, Miranda MCR, Piccoli JP, Costa FGP.   +14 more
europepmc   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source