Results 141 to 150 of about 1,668,301 (239)

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture. [PDF]

Elife
Tittelmeier J, Sandhof CA, Martin N, El-Kabarity D, Ngonza-Nito SB, Melki R, Nussbaum-Krammer C.   +6 more
europepmc   +1 more source

Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Alzheimer's disease (AD) is accompanied by persistent disturbances in brain energy metabolism, and microglial glucose metabolic reprogramming constitutes an important link among pathological protein deposition, neuroinflammation, and impaired clearance.
Yuan Chen, Fuyao Li, Junlei Zhang, Mingqing Wei, Jingnian Ni, Ting Li, Lulu Yao, Jinzhou Tian, Jing Shi   +8 more
wiley   +1 more source

Sphingolipid Metabolism Links Morphological Signatures to Immunomodulatory Potency in Human Mesenchymal Stromal Cells. [PDF]

Cell Mol Bioeng
Shah DC, Leitmann BW, Priyadarshani P, DeVeaux SA, Munoz C, Zhang Y, Rui K, Chiappa NF, Hymel LA, York W, Ogle ME, Botchwey EA, Mortensen LJ.   +12 more
europepmc   +1 more source

Cannabinoid CB1 Receptor Regulates Spinal Dorsal Horn Synaptic Plasticity in a Mouse Model of Neuropathic Pain through the CB1R/SREBP1/NAMPT/SIRT1 Metabolic Regulatory Framework

Brain and Behavior, Volume 16, Issue 10, October 2026.
Abstract Background Neuropathic pain is sustained by maladaptive synaptic plasticity in the spinal dorsal horn. Increasing evidence suggests that metabolic regulation is closely linked to synaptic function, as lipid metabolism, membrane microdomain organization, NAD+‐dependent signaling, and cellular stress‐response pathways can influence receptor ...
Lu Liu, Chenglong Wu, Hui Xia, Jie Cheng, Liang Zhong, Jiang Wu   +5 more
wiley   +1 more source

Measles virus reprograms CD4⁺ T-cell sphingolipid and fatty acid metabolism to facilitate infection. [PDF]

Front Cell Dev Biol
Grijalva Yépez MF, Cordes YL, Fekete A, Schumacher F, Kleuser B, Avota E.   +5 more
europepmc   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, Volume 101, Issue 5, Page 2103-2118, October 2026.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

A Systematic Analysis of Lipid-Protein Interactions in the Protein Data Bank. [PDF]

Biochemistry
Puri N, McShan AC.
europepmc   +1 more source

Enzymatic Synthesis of a Novel α‐Linolenic Acid‐Enriched Phytoceramide From Perilla Seed Oil and Its Multifunctional Bioactivity in Skin Barrier Repair and Anti‐Aging

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
An enzymatically synthesized α‐linolenic acid‐enriched phytoceramide from perilla seed oil (PSO) is presented. This novel ceramide demonstrates potent activation of skin barrier genes in keratinocytes and protection against UVB‐induced extracellular matrix (ECM) degradation in fibroblasts.
Jumao Yuan, Ning Hao, Borui Shi, Zhenzhen Wang, Jie Yu, Nuo Shi, Lin Lin   +6 more
wiley   +1 more source

Residual lipid-related proteomic and metabolomic signatures associated with major adverse cardiovascular events after revascularization in peripheral artery disease. [PDF]

BMC Cardiovasc Disord
Cao S, Zhang B, Li P, Luo J, Tan S, Lu C, Yu F, Yang C, Chen Z, Li Y, Diao Y.   +10 more
europepmc   +1 more source

Metabolomics Analysis Revealed That SXZ Ameliorates Cognitive Impairment in Naturally Aged Rats by Promoting Glutathione Metabolism and Inhibiting the Ferroptosis Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In aged rats, 6‐month SXZ treatment reversed spatial memory deficits and preserved hippocampal integrity. Mechanistic assays show that SXZ promotes glutathione metabolism and inhibits ferroptosis via p53/SLC7A11/GPX4 and Keap1/Nrf2/HO‐1 pathways. SXZ is a novel neuroprotective agent against age‐related cognitive decline.
Mengya Liu, Shunyi Li, Yonglin Liang, Yugui Zhang, Xutong Jia, Yongqiang Duan, Min Bai   +6 more
wiley   +1 more source