Results 31 to 40 of about 2,765,821 (261)
Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion[S]
Journal of Lipid Research, 2010 We examined the effect of Niemann-Pick disease type 2 (NPC2) protein and some late endosomal lipids [sphingomyelin, ceramide and bis(monoacylglycero)phosphate (BMP)] on cholesterol transfer and membrane fusion.
Misbaudeen Abdul-Hammed +5 more
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β-Hexosaminidase B and Sphingolipid Activator Proteins [PDF]
, 2004 Titelblatt Inhaltsverzeichnis Zusammenfassung Danksagung Abkürzungen 1 Einleitung 1 1.1 Erbliche Stoffwechselstörungen 1 1.2 Glykosphingolipide 3 1.3 Glykosphingolipid ...
Maier, Timm
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Disease Models & Mechanisms, 2017 Sphingolipidoses are inherited diseases belonging to the class of lysosomal storage diseases (LSDs), which are characterized by the accumulation of indigestible material in the lysosome caused by specific defects in the lysosomal degradation machinery ...
Julia Sellin +10 more
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The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]
, 2010 Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K. +2 more
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Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts
Journal of Lipid Research, 1998 The degradation of blood group glycolipid A-6-2 (GalNAc(α1→3)[Fucα1→2]Gal(β1→4)GlcNAc(β1→3)Gal (β1→4)Glc(β1→1′)Cer, IV2-α-fucosyl-IV3-α-N-acetylgalactosaminylneolactotetraosylceramide), tritium-labeled in its ceramide moiety, was studied in situ, in skin
Befekadu Asfaw +5 more
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Neurobiology of Disease, 2017 Saposin deficiency is a childhood neurodegenerative lysosomal storage disorder (LSD) that can cause premature death within three months of life.
Samantha J. Hindle +4 more
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Regulation of Mitogen-Activated Protein Kinases by Sphingolipid Products in Oligodendrocytes [PDF]
The Journal of Neuroscience, 1999 Sphingolipid products such as ceramide (cer), sphingosine (sph), and sphingosine-1-phosphate (SPP) are implicated in the regulation of cell growth and apoptosis. We have recently shown that cer, sph, and SPP differentially modulate ionic events in cultured oligodendrocytes (OLGs).
H, Hida +3 more
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Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets [PDF]
, 2019 This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.The understanding of the role of sphingolipid metabolism in cancer has tremendously increased in the past ten years.
Arenz, Christoph +9 more
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Frontiers in Genetics, 2019 Neuronal Ceroid Lipofuscinoses (NCLs) are progressive degenerative diseases mainly affect brain and retina. They are characterized by accumulation of autofluorescent storage material, mitochondrial ATPase subunit C, or sphingolipid activator proteins A ...
Xiao-Tun Ren +8 more
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Orm family proteins mediate sphingolipid homeostasis [PDF]
, 2010 Despite the essential roles of sphingolipids both as structural components of membranes and critical signalling molecules, we have a limited understanding of how cells sense and regulate their levels.
Ruedi Aebersold +28 more
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