Results 31 to 40 of about 10,573 (148)
Functional characterisation of the lipid raft protein stomatin [PDF]
, 2005 The function of the integral membrane protein stomatin is as yet poorly understood. Stomatin is deficient from the erythrocyte membrane of patients suffering with Overhydrated Hereditary Stomatocytosis (OHSt).
Wilkinson, Dorothy Kate
core
Identification of a Novel Sequence Involved in Lysosomal Sorting of the Sphingolipid Activator Protein Prosaposin [PDF]
Journal of Biological Chemistry, 2000 Prosaposin is synthesized as a 53-kDa protein, post-translationally modified to a 65-kDa form and further glycosylated to a 70-kDa secretory product. The 65-kDa protein is associated to Golgi membranes and is targeted to lysosomes, where four smaller nonenzymatic saposins implicated in the hydrolysis of sphingolipids are generated by its partial ...
Q, Zhao, C R, Morales
openaire +2 more sources
, 1996 Sphingolipid activator proteins (SAPs) are non-enzymatic glycoproteins required for lysosomal degradation of various sphingolipids with short oligosaccharide chains by their respective exohydrolases.
Sandhoff, Konrad +4 more
core +2 more sources
K6PC-5, a Direct Activator of Sphingosine Kinase 1, Promotes Epidermal Differentiation Through Intracellular Ca2+ Signaling [PDF]
, 2008 Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, regulates multiple cellular responses such as Ca2+ signaling, growth, survival, and differentiation.
Shin, Dong Min +7 more
core +2 more sources
Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease
, 2020 Gangliosidoses are caused by monogenic defects of a specific hydrolase or an ancillary sphingolipid activator protein essential for a specific step in the catabolism of gangliosides.
Konrad Sandhoff, Bernadette Breiden
core +1 more source
A proteomic analysis of lipid raft and GPI anchored proteins in Caenorhabditis elegans [PDF]
, 2010 Glycosylphosphatidylinositol (GPI) anchored proteins are a unique group of membrane proteins found on the surface and certain intracellular compartments of eukaryotic cells.
Rao, Wei
core
Storage of saposins A and D in infantile neuronal ceroid-lipofuscinosis
, 1993 We have isolated storage cytosomes from brain tissue of patients with infantile neuronal ceroid-lipofuscinosis. The purified storage bodies were subjected to compositional analysis which revealed a high content of proteins, accounting for 43% of dry ...
Palmer, David N. +7 more
core +1 more source
, 2004 Sphingosylphosphorylcholine (SPC) is a bioactive sphingolipid metabolite that can enhance wound healing. In a search for effectors downstream of SPC in the wound-healing process, we found that the expression of the gene for plasminogen activator ...
Piao, Yong-Jun +7 more
core +1 more source
Elucidation of a molecular mechanism controlling inflammation during bacterial infection [PDF]
, 2015 Recently we described a mechanism of gap junction-mediated communication between infected and uninfected epithelial cells that potentiates innate immunity during infection by the enteroinvasive bacterium Shigella flexneri.
Tschon, Therese
core +1 more source
, 2009 Cellular membranes enter the lysosomal compartment by endocytosis, phagocytosis, or autophagy. Within the lysosomal compartment, membrane components of complex structure are degraded into their building blocks.
Sandhoff, Konrad +2 more
core +1 more source