Results 171 to 180 of about 1,665,622 (222)

Mapping Lysosomal Storage Disorders with Neurological Features by Cellular Pathways: Towards Precision Medicine. [PDF]

Curr Issues Mol Biol
Makridou A, Sintou E, Chatzianagnosti S, Gargani S, Manthou ME, Dermitzakis I, Theotokis P.   +6 more
europepmc   +1 more source

Therapeutic potential of the sphingosine kinase 2 inhibitor opaganib. [PDF]

Pharm Sci Adv
Huang F, Zhan P, Shi X, Sun Y, Song X, Sun P, Liu B.   +6 more
europepmc   +1 more source

Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference. [PDF]

Proc Natl Acad Sci U S A
Sundman AK, Binford GJ, Montfort WR, Cordes MHJ.   +3 more
europepmc   +1 more source

Interorgan crosstalk in metabolic dysfunction-associated steatotic liver disease. [PDF]

Chin Med J (Engl)
Yang R, Fang Z, He F, Wang L.
europepmc   +1 more source

Proteomic analysis of mitochondria-ER contacts reveals key proteins involved in metabolic regulation in hepatocytes. [PDF]

Cell Commun Signal
Yang H, Wang X, Wang C, Zhang X, Kong B, Bai R, Xu X, Li Z, Xu T, Zhou M.   +9 more
europepmc   +1 more source

The Biological Significance of Calmodulin Binding to Lipids. [PDF]

Biology (Basel)
O'Day DH.
europepmc   +1 more source

Constraint-based modelling of metabolic dysregulation in Gaucher disease: mitochondrial dysfunction and disrupted cholesterol homeostasis. [PDF]

Orphanet J Rare Dis
Liu Y, Luo X, Ranjbar S, Aerts JMFG, van der Lienden M, Dardis A, Fleming RMT.   +6 more
europepmc   +1 more source

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Activator proteins and topology of lysosomal sphingolipid catabolism

Lipids and Lipid Metabolism, 1992
The lysosomal degradation of several sphingolipids by acid hydrolases is dependent on small non-enzymic cofactors, called sphingolipid activator proteins some of which have been identified as sphingolipid binding proteins. This review summarizes the information available on the structure, function, biosynthesis, gene organization and pathobiochemistry ...
Konrad Sandhoff, W Fürst
exaly   +3 more sources

Stimulation of lysosomal sphingomyelin degradation by sphingolipid activator proteins

Chemistry and Physics of Lipids, 1999
Lysosomal breakdown of glycosphingolipids with short hydrophilic carbohydrate headgroups is achieved by the simultaneous action of specific hydrolases and sphingolipid activator proteins (SAPs). Activator proteins are considered to facilitate the enzyme/substrate interaction between water-soluble enzymes and membrane-bound substrates.
Konrad Sandhoff, Klaus Ferlinz, K Ferlinz   +2 more
exaly   +3 more sources