Results 131 to 140 of about 1,105,094 (212)

Sphingomyelin synthase-related protein is a regulator of serine palmitoyltransferase. [PDF]

J Lipid Res
Li X, Li Z, Chiang YP, Worgall T, Souaiaia T, Jiang XC.   +5 more
europepmc   +1 more source

The Toll‐Like Receptor Signalling Pathway Is Altered in iPSC‐Derived Cortical Networks From People With Bipolar Disorder

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Induced pluripotent stem cell (iPSC)‐derived brain cells are widely utilised as in vitro models for several neuropsychiatric disorders, as they retain the donor's genetic profile, offering a unique opportunity to study living human brain cells and perform controlled experimental manipulations.
Bruna Panizzutti, Chiara Cristina Bortolasci, Megan Ellis, Briana Spolding, Courtney Swinton, Trang T. T. Truong, Cassie Field, Zoe Shih‐Jung Liu, Damián Hernández, Greg Roebuck, Ajeet B. Singh, Bruno Agustini, Robson Zazula, Ana C. Andreazza, Dana El Soufi El Sabbagh, Hyunjin Jeong, Olivia M. Dean, Jee Hyun Kim, Michael Berk, Ken Walder   +19 more
wiley   +1 more source

Endolysosomal Impact of Elevated Ceramide Levels Revealed by Optical and Ultrastructural Nanoprobing. [PDF]

ACS Nano
Feng Y, Gärber F, Saied EM, Singh H, Spedalieri C, Werner S, Pratsch C, Arenz C, Seifert S, Kneipp J.   +9 more
europepmc   +1 more source

Absorption and Effects of Patch Test Preparations of Hydroperoxides of Limonene and Hydroperoxides of Linalool in Human Ex Vivo Skin

Contact Dermatitis, Volume 95, Issue 2, Page 159-168, August 2026.
This study mimics clinical patch testing for the diagnosis of allergic contact dermatitis, by application of patch test preparations of fragrance terpenes to ex vivo human skin samples. The study investigates the penetration of linalool hydroperoxide and limonene hydroperoxide in skin, alongside an analysis of the lipid‐modifying effects of the patch ...
Aoife Clancy, Lina Hagvall, Per Malmberg, Niamh M. O'Boyle   +3 more
wiley   +1 more source

Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin-Regulated Fashion. [PDF]

J Neurochem
Hodul M, Lane-Donovan C, Cheang ES, Gao V, Sampognaro PJ, Mambou EA, Yang Z, Kao AW.   +7 more
europepmc   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, Volume 293, Issue 15, Page 4508-4532, August 2026.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Ceramide in Type 2 Diabetes and Obesity: Modulation by Nutrients and Dietary Patterns and Opportunities to Prevent and/or Manage Metabolic-Related Conditions. [PDF]

Metabolites
Gaggini M, Suman AF, Vassalle C.
europepmc   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

High-resolution sphingolipid analysis in vitro using LC-qToF MS. [PDF]

Methods Enzymol
Chitkara S, Atilla-Gokcumen GE.
europepmc   +1 more source

Broken Balance: Emerging Cross-Talk Between Proteostasis and Lipostasis in Neurodegenerative Diseases. [PDF]

Cells
Tittelmeier J, Nussbaum-Krammer C.
europepmc   +1 more source