Results 171 to 180 of about 1,105,094 (212)

Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism

Biochimie, 2016
Glycosphingolipids and sphingolipids of cellular plasma membranes (PMs) reach luminal intra-lysosomal vesicles (LVs) for degradation mainly by pathways of endocytosis. After a sorting and maturation process (e.g. degradation of sphingomyelin (SM) and secretion of cholesterol), sphingolipids of the LVs are digested by soluble enzymes with the help of ...
Konrad Sandhoff
exaly   +4 more sources

Stimulation of lysosomal sphingomyelin degradation by sphingolipid activator proteins

Chemistry and Physics of Lipids, 1999
Lysosomal breakdown of glycosphingolipids with short hydrophilic carbohydrate headgroups is achieved by the simultaneous action of specific hydrolases and sphingolipid activator proteins (SAPs). Activator proteins are considered to facilitate the enzyme/substrate interaction between water-soluble enzymes and membrane-bound substrates.
Konrad Sandhoff, Klaus Ferlinz, K Ferlinz   +2 more
exaly   +4 more sources

PRINCIPLES OF LYSOSOMAL MEMBRANE DIGESTION: Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids

Annual Review of Cell and Developmental Biology, 2005
Sphingolipids and glycosphingolipids are membrane components of eukaryotic cell surfaces. Their constitutive degradation takes place on the surface of intra-endosomal and intra-lysosomal membrane structures. During endocytosis, these intra-lysosomal membranes are formed and prepared for digestion by a lipid-sorting process during which their ...
Thomas Kolter, Konrad Sandhoff
exaly   +4 more sources

12 Activator Proteins for Sphingolipid Hydrolysis

, 1983
Publisher Summary This chapter focuses on the various activator proteins used for the sphingolipid hydrolysis. Mraz et al. found that human hepatic activator protein that was specific for stimulating the hydrolysis of galactosylceramide sulfate by human enzyme could also stimulate the same reaction catalyzed by acidic sulfatases isolated from various
Yu-Teh Li, Su-chen Li
semanticscholar   +2 more sources

Pathological study of mice with total deficiency of sphingolipid activator proteins (SAP knockout mice)

Acta Neuropathologica, 1998
Kyoichi Suzuki, Suzuki Kinuko, Nobuya Fujita   +2 more
exaly   +2 more sources

Intracellular trafficking of glycosphingolipids: Role of sphingolipid activator proteins in the topology of endocytosis and lysosomal digestion

FEBS Letters, 1994
K. Sandhoff, A. Klein
exaly   +2 more sources

Sphingolipid activator proteins (SAPS) are stored together with glycosphingolipids in the infantile neuronal ceroid-lipofuscinosis (INCL)

American Journal of Medical Genetics Part A, 1995
Konrad Sandhoff, J Tyynelä, M Haltia
exaly   +2 more sources

Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus

Science, 1988
David Wenger, John S O'Brien, Arvan L Fluharty   +2 more
exaly   +2 more sources

Physiological relevance of sphingolipid activator proteins in cultured human fibroblasts

Biochimie, 2003
Bernadette Breiden, Konrad Sandhoff
exaly   +2 more sources