Results 131 to 140 of about 10,624 (209)

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

The Dietary Protein Source Modulates Obesity Development and Induces Distinct Plasma Lipid Profiles and Transcriptome Profiles in Liver and Adipose Tissue

Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
By performing plasma metabolomics analyses combined with RNA sequencing and gene set enrichment analyses of liver, muscle, white‐ and brown‐adipose tissue in mice, we aimed to decipher the metabolic output and pathways modulated by intake of different dietary proteins.
Lene S. Myrmel, Even Fjære, Annette Bernhard, Josef D. Rasinger, Ole Jakob Nøstbakken, Helene Søiland, Philipp Rausch, Martin von Bergen, Ulrike Rolle‐Kampzcyk, Liang Xiao, Hanlin Zhou, Guibo Li, Karsten Kristiansen, Lise Madsen   +13 more
wiley   +1 more source

Mapping Lysosomal Storage Disorders with Neurological Features by Cellular Pathways: Towards Precision Medicine. [PDF]

Curr Issues Mol Biol
Makridou A, Sintou E, Chatzianagnosti S, Gargani S, Manthou ME, Dermitzakis I, Theotokis P.   +6 more
europepmc   +1 more source

Dietary Titanium Dioxide (E171) Alters the Colon Transcriptome—Evidence From a Human Dietary Intervention Study

Molecular Nutrition &Food Research, Volume 70, Issue 16, 27 August 2026.
Oral E171 exposure (2 mg/kg body weight/day) in a randomized cross‐over study of 31 healthy adults increased fecal titanium and blood superoxide while altering the colon transcriptome and enriching 73 pathways linked to oxidative stress, metabolism, and colorectal cancer.
Nicolaj S. Bischoff, Anna K. Undas, Greet van Bemmel, Marcel van Herwijnen, Marcha Verheijen, Simone G. Van Breda, Jacco J. Briedé, Lana Drenth‐Brink, Marcella Peelen‐Buijs, Iris Elferink, Héloïse Proquin, Henk van Loveren, Ad A. van Bodegraven, Dick T. H. M. Sijm, Theo M. de Kok   +14 more
wiley   +1 more source

Therapeutic potential of the sphingosine kinase 2 inhibitor opaganib. [PDF]

Pharm Sci Adv
Huang F, Zhan P, Shi X, Sun Y, Song X, Sun P, Liu B.   +6 more
europepmc   +1 more source

Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Mitochondria respond to proteotoxic stress through the mitochondrial unfolded protein response, traditionally viewed as a transcriptional program that restores proteostasis by inducing chaperones and proteases. Emerging evidence indicates that mitochondrial membrane remodeling constitutes an additional adaptive component of this response ...
Lena J. Reichert, F.‐Nora Vögtle, Carlotta Peselj   +2 more
wiley   +1 more source

Interorgan crosstalk in metabolic dysfunction-associated steatotic liver disease. [PDF]

Chin Med J (Engl)
Yang R, Fang Z, He F, Wang L.
europepmc   +1 more source

HvarAKR1B1‐mediated tolerance in Hippodamia variegata: Deciphering the metabolic adaptation and fitness costs under prolonged starvation

Pest Management Science, Volume 82, Issue 8, Page 7903-7914, August 2026.
Starvation stress significantly affected the growth and development of Hippodamia variegata. Combined transcriptome and metabolome analysis and RNA interference verification revealed that HvarAKR1B1 may be involved in the response of Hippodamia variegata to starvation stress.
Bing‐mei Song, De‐qin Hu, Yuan Li, Wang‐quan Jiao, Xiao‐li Ma, Hong‐sheng Pan   +5 more
wiley   +1 more source

Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference. [PDF]

Proc Natl Acad Sci U S A
Sundman AK, Binford GJ, Montfort WR, Cordes MHJ.   +3 more
europepmc   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, Volume 7, Issue 4, August 2026.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source