Results 161 to 170 of about 10,624 (209)

CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis. [PDF]

J Transl Med
Wang Y, Chen X, You G, Yu S, Chen C, Lian R, Diao L, Li Y, Yin T.   +8 more
europepmc   +1 more source

Sphingolipid Metabolism and Signalling Pathways in Heart Failure: From Molecular Mechanism to Therapeutic Potential. [PDF]

J Inflamm Res
Zhao M, Bian R, Xu X, Zhang J, Zhang L, Zheng Y.   +5 more
europepmc   +1 more source

Discovery of novel repurposed anthelminthics against <i>Trichinella spiralis</i> and albendazole-resistant nematodes through metabolomics-guided virtual screening. [PDF]

Curr Res Parasitol Vector Borne Dis
Chienwichai P, Tipthara P, Tarning J, Thiangtrongjit T, Supasawat P, Adisakwattana P, Reamtong O.   +6 more
europepmc   +1 more source

Lung Tissue Metabolome Investigation Reveals the In Vivo Effects of Zhuye Shigao Decoction in an LPS-Induced Acute Pneumonia Model in Mice. [PDF]

Mediators Inflamm
Tang H, Sun Z, Qin W, Cai G, Gao W, Wang Y, Gong J.   +6 more
europepmc   +1 more source

Targeting Sphingolipids in Breast Cancer: From Tumor Biology to Therapeutic Strategies. [PDF]

Oncol Res
Kim MH, Huh B, Park JW, Park WJ.
europepmc   +1 more source

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Activator proteins and topology of lysosomal sphingolipid catabolism

Lipids and Lipid Metabolism, 1992
The lysosomal degradation of several sphingolipids by acid hydrolases is dependent on small non-enzymic cofactors, called sphingolipid activator proteins some of which have been identified as sphingolipid binding proteins. This review summarizes the information available on the structure, function, biosynthesis, gene organization and pathobiochemistry ...
Konrad Sandhoff, W Fürst
exaly   +3 more sources

Stimulation of lysosomal sphingomyelin degradation by sphingolipid activator proteins

Chemistry and Physics of Lipids, 1999
Lysosomal breakdown of glycosphingolipids with short hydrophilic carbohydrate headgroups is achieved by the simultaneous action of specific hydrolases and sphingolipid activator proteins (SAPs). Activator proteins are considered to facilitate the enzyme/substrate interaction between water-soluble enzymes and membrane-bound substrates.
Konrad Sandhoff, Klaus Ferlinz, K Ferlinz   +2 more
exaly   +3 more sources

Sphingolipid hydrolase activator proteins and their precursors

Biochemical and Biophysical Research Communications, 1989
Activator proteins for sphingolipid hydrolases (saposins) are small acidic, heat-stable glycoproteins that stimulate the hydrolysis of sphingolipids by lysosomal enzymes. The molecular mass of each stimulator is about 10 kDa, but glycosylated forms of higher mass exist too.
Akira Sano, Shû-Ichi Ueno, Yasuo Kakimoto   +2 more
exaly   +3 more sources

Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism

Biochimie, 2016
Glycosphingolipids and sphingolipids of cellular plasma membranes (PMs) reach luminal intra-lysosomal vesicles (LVs) for degradation mainly by pathways of endocytosis. After a sorting and maturation process (e.g. degradation of sphingomyelin (SM) and secretion of cholesterol), sphingolipids of the LVs are digested by soluble enzymes with the help of ...
Konrad Sandhoff
exaly   +3 more sources