Results 151 to 160 of about 1,668,301 (239)

Genetic, Lipid, Fungal Microbiome and Neuroinflammatory Links Between Seborrheic Dermatitis and Parkinson's Disease: A Narrative Review. [PDF]

Genes (Basel)
Kefala V, Oikonomou E, Sfyri E, Grech VS, Tertipi N, Andreou E, Rallis E.   +6 more
europepmc   +1 more source

Hepatic HIF2α Modulates Extra‐Hepatic Disease‐Associated Phenotypes During Metabolic Dysfunction‐Associated Steatotic Liver Disease

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
High fat, high fructose, high cholesterol “GAN” diet feeding in mice induces MASLD, cardiac dysfunction, loss of lean mass, and hyperinsulinaemia. Hepatocyte‐specific deletion of HIF2α also causes cardiac dysfunction and loss of lean mass but prevents GAN induced hyperinsulinaemia and cardiac sympathetic dominance without preventing MASLD.
Lorenz M. W. Holzner, Rosa M. Korpershoek, Youguo Niu, Anna Cochrane, Paula M. Darwin, Julia Babuta, Areesha Nazeer, Cecilia Castro, Alice P. Sowton, Alice E. Knapton, Benjamin D. Thackray, Julian L. Griffin, Zoe Hall, Dino A. Giussani, Rob C. I. Wüst, Andrew J. Murray   +15 more
wiley   +1 more source

A Contemporary Pathomechanistic Nosology of Inherited Lysosomal Disorders. [PDF]

J Inherit Metab Dis
McCarron EP, Blau N, Eden ER, Platt FM, Aerts JM, Jones SA, Ferreira CR, Stepien KM.   +7 more
europepmc   +1 more source

Context‐dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Divergent triggering receptor expressed on myeloid cells 2 (TREM2) signalling pathways instruct myeloid cell adaptation towards neuroprotective disease‐associated microglia (DAM)/lipid‐associated macrophage (LAM) or immunosuppressive tumour‐associated macrophage (TAM) phenotypes.
Yaqing Lv, Mingpeng Shi, Yongfei Zhao, Yi Yu, Jiawei Lv, Hai Zhao   +5 more
wiley   +1 more source

Lipid metabolism drives podocyte injury in diabetic kidney disease. [PDF]

Front Immunol
Shang J, Zeng Z, Chai S, Lv X, Han X, Ma B, Xu Y, Wang R, Lv Z.   +8 more
europepmc   +1 more source

Integrated Multi‐Omics and Single‐Cell Analyses Implicate NOX4 as an Icariin‐Associated Oxidative Stress Regulatory Node in Gastric Cancer

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
NOX4 represents a candidate icariin‐associated regulatory node in gastric cancer and may contribute to the cellular response to icariin through redox‐related signaling. ABSTRACT Icariin, a prenylated flavonoid glycoside from Epimedium species, is a representative dietary polyphenol with antioxidant, anti‐inflammatory, and antitumor properties.
Na Liang, Junyan Li, Zuchao Luo, Zijuan Song, Liyuan Zhang, Chengyi Zou, Chunming Li, Bochen Pan, Jiawei Yang   +8 more
wiley   +1 more source

Sphingolipid metabolism and hematologic disorders: current understanding and future directions. [PDF]

Front Physiol
Kuang Z, Huang T, Chen G.
europepmc   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, Volume 5, Issue 5, Page 495-513, October 2026.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Candida glabrata YPK2 is a multidrug susceptibility locus. [PDF]

Genetics
Simonicova L, Conway TP, Krüger T, Brakhage AA, Moye-Rowley WS.   +4 more
europepmc   +1 more source

Network Pharmacology‐Based Prediction and In Vivo Validation of Fumonisin B1‐Induced Liver Injury and Early Fibrosis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
This study integrates network pharmacology and an in vivo mouse model to elucidate the mechanisms underlying Fumonisin B1 (FB1)‐induced liver injury and early fibrosis. In silico predictions identified 56 core targets, with TP53, EP300, and MTOR demonstrating strong molecular docking affinities for FB1. In vivo validation showed that FB1 exposure (5 mg/
Na Li, Wen Sun, Xuehui Liu, Xinyu Liu, Yunhan Xie, Hao Xu, Linlin Xu, Jia Zang, Leilei Zhang, Liang Wu, Keke Shao   +10 more
wiley   +1 more source