Distinct Metabolic Signatures Linked to High-Resolution Computed Tomography Radiographic Phenotypes in Stable and Progressive Fibrotic Lung Disease. [PDF]
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Exploring Causal Associations Between Plasma Metabolites and Autism Spectrum Disorder. [PDF]
Shi S, Baranova A, Cao H, Zhang F.
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Exploring the role of 338 cerebrospinal fluid metabolites in primary brain malignancies risk: a Mendelian randomization study. [PDF]
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Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001Tissue injury in inflammation involves the release of several cytokines that activate sphingomyelinases and generate ceramide. In the lung, the impaired metabolism of surfactant phosphatidylcholine (PC) accompanies this acute and chronic injury. These effects are long-lived and extend beyond the time frame over which tumor necrosis factor (TNF)-α and ...
J, Vivekananda, D, Smith, R J, King
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Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers
Biochemistry, 1992Pressure versus fluid spacing relations have been obtained for sphingomyelin bilayers in the gel phase and equimolar sphingomyelin/cholesterol in the liquid-crystalline phase by the use of X-ray diffraction analysis of osmotically stressed aqueous dispersions and oriented multilayers.
T J, McIntosh +3 more
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Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases
Chemistry and Physics of Lipids, 2016Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing number of physiologic and pathophysiologic processes that include cell cycle, apoptosis, angiogenesis, stress and inflammatory responses. Sphingomyelin is an important structural component of biological membranes, and one of the end-points in the synthesis of ...
Mohamad, Adada +2 more
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Molecular packing in sphingomyelin bilayers and sphingomyelin/phospholid mixtures
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2003The molecular packing properties of sphingomyelin (SM) from egg yolk were studied. The influence of the spontaneous curvature of SM on the phase behaviour of SM/dodecane/water systems was investigated. A comparison was made to a previous study by Lindblom et al. (Liq. Cryst. 3 (1988) 783), of the phase behaviour of dipalmitoylphosphatidylcholine (DPPC)/
Tomas, Byström, Göran, Lindblom
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AN investigation of marine phospholipids in this laboratory necessitated the determination of Sphingomyelin. Sphingomyelin is frequently estimated by determining sphingosine according to the method of McKibbin and Taylor1. This method consists of the separation of sphingosine from other nitrogenous bases by extraction from an aqueous acid solution with
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Regulation of sphingomyelin metabolism
Pharmacological Reports, 2016Sphingolipids (SFs) represent a large class of lipids playing diverse functions in a vast number of physiological and pathological processes. Sphingomyelin (SM) is the most abundant SF in the cell, with ubiquitous distribution within mammalian tissues, and particularly high levels in the Central Nervous System (CNS).
Kamil Bienias +4 more
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Sphingomyelin synthases and testicular function
Expert Review of Endocrinology & Metabolism, 2008Sphingomyelin synthase (SMS) is a cellular enzyme that catalyzes de novo synthesis of sphingomyelin (SM), which is a vital lipid component of cell membranes. Both members of the SMS family, SMS1 and SMS2, are found in mammalian testes and they are located in distinctive subcellular compartments, with SMS1 in the Golgi apparatus and SMS2 in the plasma ...
Cheng, CY, Mruk, DD, Wong, EWP, Lee, NPY
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