Results 171 to 180 of about 7,161 (190)

Analysis of the sphingomyelin phosphodiesterase 1 gene (SMPD1) in Turkish Niemann–Pick disease patients: Mutation profile and description of a novel mutation

Gene, 2013
Niemann-Pick disease (NPD) is a lysosomal storage disorder that results from the deficiency of a lysosomal enzyme, acid sphingomyelinase. Niemann-Pick disease type A and B is caused by mutations in the sphingomyelin phosphodiesterase gene (SMPD1) coding for ASM.
Karaca, E., Onay, H., Ucar, S. Kalkan, Coker, M., Cogulu, O., Özkınay, Ferda, Aykut, A.   +6 more
openaire   +4 more sources

Sphingomyelin Phosphodiesterase 3 Enhances Cytodifferentiation of Periodontal Ligament Cells

Journal of Dental Research, 2016
Sphingomyelin phosphodiesterase 3 ( Smpd3), which encodes neutral sphingomyelinase 2 (nSMase2), is a key molecule for skeletal development as well as for the cytodifferentiation of odontoblasts and alveolar bone. However, the effects of nSMase2 on the cytodifferentiation of periodontal ligament (PDL) cells are still unclear. In this study, the authors
S, Miyauchi, J, Kitagaki, R, Masumoto, A, Imai, K, Kobayashi, A, Nakaya, S, Kawai, C, Fujihara, Y, Asano, M, Yamashita, M, Yanagita, S, Yamada, M, Kitamura, S, Murakami   +13 more
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Podocyte sphingomyelin phosphodiesterase acid-like 3b decreases among children with idiopathic nephrotic syndrome

Clinical and Experimental Nephrology, 2020
Sphingomyelin phosphodiesterase acid-like 3b (SMPDL-3b), a regulator of the cytoskeleton, is expressed on podocytes. Recent reports present evidence that it is directly targeted by rituximab in the treatment of intractable nephrotic syndrome. However, the implications of SMPDL-3b for treatment of paediatric-onset idiopathic nephrotic syndrome (INS ...
Shojiro Watanabe, Koji Hirono, Tomomi Aizawa, Koji Tsugawa, Kensuke Joh, Tadaatsu Imaizumi, Hiroshi Tanaka   +6 more
openaire   +2 more sources

RNA interference targeting of sphingomyelin phosphodiesterase 1 protects human granulosa cells from apoptosis

Journal of Obstetrics and Gynaecology Research, 2009
AbstractAim:  Sphingomyelin phosphodiesterase 1 (SMPD1) plays an essential role in initiating the female germ cell death signal. To evaluate whether RNA interference has potential as a new approach in germ cell protection, we tested the effect of SMPD1 knockdown on human granulosa cells in vitro.Methods:  We designed and synthesized three small ...
Jun, Gao, Ren-Li, Zhang, Can-Quan, Zhou, Yun, Ma, Guang-Lun, Zhuang   +4 more
openaire   +2 more sources

Regulation of Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A) by Liver X Receptors

Molecular Pharmacology, 2012
Liver X receptor (LXR) α and LXRβ function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.
Paul B, Noto, Yuri, Bukhtiyarov, Meng, Shi, Brian M, McKeever, Gerard M, McGeehan, Deepak S, Lala   +5 more
openaire   +2 more sources

Sphingomyelin phosphodiesterase 1 (SMPD1) mediates the attenuation of myocardial infarction-induced cardiac fibrosis by astaxanthin

Biochemical and Biophysical Research Communications, 2018
Uncontrolled cardiac fibrosis following myocardial infarction (MI) is a critical pathological change leading to heart failure. Current pharmacotherapies are limited by unsatisfactory efficacy and undesired systemic side effects. Astaxanthin (ASX) is a natural carotenoid with strong antioxidant and anti-inflammatory activities.
Yu, Shi, Peng, Lin, Xiaoning, Wang, Guangmei, Zou, Kefeng, Li   +4 more
openaire   +2 more sources

Radiation-Induced Nephrotoxicity: Role of Sphingomyelin Phosphodiesterase Acid-like 3b

International Journal of Radiation Oncology*Biology*Physics
Radiation nephropathy (RN) can be a significant late complication after radiation therapy (RT) for abdominal and paraspinal tumors. The mechanisms for the development of RN are thought to involve disruption of podocyte function, leading to podocyte cell death and, finally, impaired renal function.
Anis Ahmad, Shamroop Kumar Mallela, Saba Ansari, Mohammed Alnukhali, Misha Ali, Sandra Merscher, Alan Pollack, Youssef H. Zeidan, Alessia Fornoni, Brian Marples   +9 more
openaire   +2 more sources

Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol

Human Genetics, 2003
Type A and B forms of Niemann-Pick disease (NPD) are lipid storage disorders caused by deficient activity of the enzyme acid sphingomyelinase (aSMase) and the resulting accumulation of sphingomyelin in tissues. In the present study, we investigated two family members who had been diagnosed with Type B NPD and who had a severe decrease in plasma high ...
Ching Yin, Lee, Larbi, Krimbou, Jérôme, Vincent, Chantal, Bernard, Pierre, Larramée, Jacques, Genest, Michel, Marcil   +6 more
openaire   +2 more sources

Expression, immunolocalization, and serological reactivity of a novel sphingomyelin phosphodiesterase-like protein, an excretory/secretory antigen from Clonorchis sinensis

Parasitology Research, 2013
Clonorchiasis, caused by Clonorchis sinensis infection, is a zoonotic parasitic disease of hepatobiliary system in which the proteins released by adult are major pathogenetic factors. In this study, we first characterized a putative sphingomyelin phosphodiesterase (CsSMPase) A-like secretory protein, which was highly expressed in the adult worm.
Yanwei, Huang, Youwei, Zheng, Yuzhe, Li, Mei, Yang, Ting, Li, Suxiang, Zeng, Xinbing, Yu, Huaiqiu, Huang, Xuchu, Hu   +8 more
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[siRNAs targetting sphingomyelin phosphodiesterase 1 protect mouse oocytes from apoptosis].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011
To investigate the potential of siRNAs targeting sphingomyelin phosphodiesterase 1 (SMPD1) in protecting the oocytes from apoptosis, and explore new approaches to female fertility preservation.Chemically synthesized siRNA targeting SMPD1 were introduced into mouse oocytes retrieved by hyperstimulation, and the cell apoptosis was analyzed by comic assay
Ren-Li, Zhang, Jin-Xiu, Meng, An-Ming, Wen, Yue-Shen, Huang, Can-Quan, Zhou, Kai, Wang, Lei, Jia, Cai-Xia, Liu, Xin-Yan, Deng, Xi-Gu, Chen   +9 more
openaire   +1 more source